UniProt P10747
T-cell-specific surface glycoprotein CD28 (P10747)
T-cell-specific surface glycoprotein CD28 (UniProt P10747): 17 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P10747
- Protein
- T-cell-specific surface glycoprotein CD28
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
18 records of P10747 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YJD | Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1) | x-ray diffraction | C | — | — |
| 1YJD | Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1) | x-ray diffraction | C | — | — |
| 3WA4 | Grb2 SH2 domain/CD28-derived peptide complex | x-ray diffraction | B | — | — |
| 3WA4 | GRB2 SH2 DOMAIN/CD28-derived peptide complex | x-ray diffraction | B | — | — |
| 5AUL | PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex | x-ray diffraction | B | — | — |
| 5AUL | PI3K P85 C-terminal SH2 DOMAIN/CD28-derived peptide complex | x-ray diffraction | B | — | — |
| 5GJH | Gads SH2 domain/CD28-derived peptide complex | x-ray diffraction | B, D | — | — |
| 5GJH | Gads SH2 DOMAIN/CD28-derived peptide complex | x-ray diffraction | B, D | — | — |
| 5GJI | PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex | x-ray diffraction | B | SO4 | — |
| 5GJI | PI3K P85 N-terminal SH2 DOMAIN/CD28-derived peptide complex | x-ray diffraction | B | — | — |
| 6O8D | Anti-CD28xCD3 CODV Fab bound to CD28 | x-ray diffraction | C | NAG | — |
| 6O8D | Anti-CD28XCD3 codv Fab bound to CD28 | x-ray diffraction | C | NAG | — |
| 7PPN | SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195) | x-ray diffraction | B | — | 2 (best 0.51) |
| 7VU5 | Structure of the transmembrane domain of the CD28 dimer | solution nmr | A, B | — | — |
| 7VU5 | Structure of the transmembrane domain of the CD28 dimer | solution nmr | A, B | — | — |
| 8S6Z | CD28 in complex with the antibody Fab fragment AI3 | x-ray diffraction | C, F | NAG, ZN | 1 (best 0.26) |
| 8W2V | Solution Structure of the CD28 hinge used in chimeric antigen receptor (CAR) T-cells | solution nmr | A | — | — |
| P10747 | AlphaFold monomer V2.0 prediction for T-cell-specific surface glycoprotein CD28 (P10747) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1YJD chain C against the predicted model P10747: TM-score 0.98, RMSD 0.72 Å
- 1YJD chain C against the predicted model P10747: TM-score 0.98, RMSD 0.72 Å
- 8S6Z chain F against the predicted model P10747: TM-score 0.97, RMSD 0.78 Å
- 8S6Z chain C against the predicted model P10747: TM-score 0.97, RMSD 0.83 Å
- 6O8D chain C against the predicted model P10747: TM-score 0.89, RMSD 1.57 Å
- 6O8D chain C against the predicted model P10747: TM-score 0.89, RMSD 1.57 Å
- 7PPN chain B against the predicted model P10747: TM-score 0.77, RMSD 0.39 Å
- 5AUL chain B against the predicted model P10747: TM-score 0.64, RMSD 0.67 Å
- 5AUL chain B against the predicted model P10747: TM-score 0.64, RMSD 0.67 Å
- 3WA4 chain B against the predicted model P10747: TM-score 0.62, RMSD 1.44 Å
Elsewhere
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