MolNFT v1 · #119916 · protein

PI3K P85 N-terminal SH2 DOMAIN/CD28-derived peptide complex

5GJI · Phosphatidylinositol 3-kinase regulatory subunit alpha: “PI3K P85 N-terminal SH2 DOMAIN/CD28-derived peptide complex”. X-ray diffraction, 1 ligand (SO4). MolNFT v1 #119916 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5GJI
Type: protein
Length: 115 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylinositol 3-kinase regulatory subunit alpha; T-cell-specific surface…
UniProt: P27986, P10747
Ligands: SO4

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylinositol 3-kinase regulatory subunit alpha	protein	107	24% helix, 28% strand	P27986
B	T-cell-specific surface glycoprotein CD28	protein	8	0% helix, 13% strand	P10747

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B
GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 563 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

5GJI · PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
P10747 · AlphaFold monomer V2.0 prediction for T-cell-specific surface glycoprotein CD28 (P10747) · a predicted model of the same protein · chain B against A, TM-score 0.57

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27986
Every structure of UniProt P10747
Elsewhere: RCSB PDB 5GJI · PDBe 5GJI · UniProt P27986 · UniProt P10747

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