UniProt P27986
Phosphatidylinositol 3-kinase regulatory subunit alpha (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (UniProt P27986): 135 experimental structures on GenesisL1, 12 ligands bound, 226 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P27986
- Protein
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Experimental structures
- 135
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 226 · 30 records with a druggable one
Structures
135 records of P27986 in the MolNFT archive: 135 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A0N | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase complexed with the synthetic… | solution nmr | A | — | — |
| 1A0N | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase complexed with the synthetic… | solution nmr | A | — | — |
| 1AZG | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase kinase complexed with the… | solution nmr | A | — | — |
| 1AZG | NMR study of the SH3 domain from fyn proto-oncogene tyrosine kinase kinase complexed with the… | solution nmr | A | — | — |
| 1H9O | Phosphatidylinositol 3-kinase, P85-alpha subunit: C-terminal SH2 domain complexed with a TYR751… | x-ray diffraction | A | — | — |
| 1H9O | Phosphatidylinositol 3-kinase, P85-alpha subunit: C-terminal SH2 domain complexed with a TYR751… | x-ray diffraction | A | — | — |
| 1PBW | Structure of BCR-homology (bh) domain | x-ray diffraction | A, B | — | — |
| 1PBW | Structure of BCR-homology (bh) domain | x-ray diffraction | A, B | — | — |
| 1PHT | Phosphatidylinositol 3-kinase P85-alpha subunit SH3 domain, residues 1-85 | x-ray diffraction | A | — | — |
| 1PHT | Phosphatidylinositol 3-kinase P85-alpha subunit SH3 domain, residues 1-85 | x-ray diffraction | A | — | — |
| 1PIC | Phosphatidylinositol 3-kinase, P85-alpha subunit: C-terminal SH2 domain complexed with a TYR751… | solution nmr | A | — | — |
| 1PIC | Phosphatidylinositol 3-kinase, P85-alpha subunit: C-terminal SH2 domain complexed with a TYR751… | solution nmr | A | — | — |
| 1PKS | Structure of the PI3K SH3 domain and analysis of the SH3 family | solution nmr | A | — | — |
| 1PKS | Structure of the PI3K SH3 domain and analysis of the SH3 family | solution nmr | A | — | — |
| 1PKT | Structure of the PI3K SH3 domain and analysis of the SH3 family | solution nmr | A | — | — |
| 1PKT | Structure of the PI3K SH3 domain and analysis of the SH3 family | solution nmr | A | — | — |
| 2IUG | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain | x-ray diffraction | A | — | — |
| 2IUG | Crystal structure of the PI3-kinase P85 N-terminal SH2 domain | x-ray diffraction | A | — | — |
| 2IUH | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl… | x-ray diffraction | A | — | — |
| 2IUH | Crystal structure of the PI3-kinase P85 N-terminal SH2 domain in complex with C-kit phosphotyrosyl… | x-ray diffraction | A | — | — |
| 2IUI | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl… | x-ray diffraction | A, B | — | — |
| 2IUI | Crystal structure of the PI3-kinase P85 N-terminal SH2 domain in complex with pdgfr phosphotyrosyl… | x-ray diffraction | A, B | — | — |
| 2RD0 | Structure of a human p110alpha/p85alpha complex | x-ray diffraction | B | — | — |
| 2RD0 | Structure of a human P110ALPHA/P85ALPHA complex | x-ray diffraction | B | — | — |
| 2V1Y | Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the… | x-ray diffraction | B | — | — |
| 2V1Y | Structure of a phosphoinositide 3-kinase alpha adaptor- binding domain (abd) in a complex with the… | x-ray diffraction | B | — | — |
| 3HHM | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug… | x-ray diffraction | B | — | — |
| 3HHM | Crystal structure of P110ALPHA H1047R mutant in complex with NISH2 of P85ALPHA and the drug… | x-ray diffraction | B | — | — |
| 3HIZ | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha | x-ray diffraction | B | — | — |
| 3HIZ | Crystal structure of P110ALPHA H1047R mutant in complex with NISH2 of P85ALPHA | x-ray diffraction | B | — | — |
| 3I5R | PI3K SH3 domain in complex with a peptide ligand | x-ray diffraction | A | — | — |
| 3I5R | PI3K SH3 domain in complex with a peptide ligand | x-ray diffraction | A | — | — |
| 3I5S | Crystal structure of PI3K SH3 | x-ray diffraction | A, B, C, D | — | — |
| 3I5S | Crystal structure of PI3K SH3 | x-ray diffraction | A, B, C, D | — | — |
| 4A55 | Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 | x-ray diffraction | B | — | — |
| 4A55 | Crystal structure of P110ALPHA in complex with ISH2 of P85ALPHA and the inhibitor pik-108 | x-ray diffraction | B | — | — |
| 4JPS | Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors | x-ray diffraction | B | — | — |
| 4JPS | Co-crystal structures of the lipid kinase PI3K alpha with pan and isoform selective inhibitors | x-ray diffraction | B | — | — |
| 4L1B | Crystal Structure of p110alpha complexed with niSH2 of p85alpha | x-ray diffraction | B | — | — |
| 4L1B | Crystal structure of P110ALPHA complexed with NISH2 of P85ALPHA | x-ray diffraction | B | — | — |
| 4L23 | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 | x-ray diffraction | B | — | — |
| 4L23 | Crystal structure of P110ALPHA complexed with NISH2 of P85ALPHA and pi-103 | x-ray diffraction | B | — | — |
| 4L2Y | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d | x-ray diffraction | B | — | — |
| 4L2Y | Crystal structure of P110ALPHA complexed with NISH2 of P85ALPHA and compound 9D | x-ray diffraction | B | — | — |
| 4OVU | Crystal Structure of p110alpha in complex with niSH2 of p85alpha | x-ray diffraction | B | — | — |
| 4OVU | Crystal structure of P110ALPHA in complex with NISH2 of P85ALPHA | x-ray diffraction | B | — | — |
| 4OVV | Crystal Structure of PI3Kalpha in complex with diC4-PIP2 | x-ray diffraction | B | — | — |
| 4OVV | Crystal structure of PI3KALPHA in complex with DIC4-PIP2 | x-ray diffraction | B | — | — |
| 4WAF | Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha | x-ray diffraction | B | — | — |
| 4WAF | Crystal structure of a novel TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE in an engineered PI3K alpha | x-ray diffraction | B | — | — |
| 4YKN | Pi3K alpha lipid kinase with Active Site Inhibitor | x-ray diffraction | A | — | — |
| 4YKN | PI3K alpha lipid kinase with active site inhibitor | x-ray diffraction | A | — | — |
| 4ZOP | Co-crystal structure of lipid kinase PI3K alpha with a selective phosphatidylinositol-3 kinase… | x-ray diffraction | B | — | — |
| 5AUL | PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex | x-ray diffraction | A | — | — |
| 5AUL | PI3K P85 C-terminal SH2 DOMAIN/CD28-derived peptide complex | x-ray diffraction | A | — | — |
| 5FI4 | Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse… | x-ray diffraction | B | — | — |
| 5FI4 | Discovery of IMIDAZO[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse… | x-ray diffraction | B | — | — |
| 5GJI | PI3K P85 N-terminal SH2 DOMAIN/CD28-derived peptide complex | x-ray diffraction | A | — | — |
| 5ITD | Crystal structure of PI3K alpha with PI3K delta inhibitor | x-ray diffraction | B | — | — |
| 5ITD | Crystal structure of PI3K alpha with PI3K delta inhibitor | x-ray diffraction | B | — | — |
75 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 5 records
- 70V · 2-methylcyclohexane-1,3-dione · in 2 records
- 71F · 2-methoxybenzoic acid · in 2 records
- 71J · trans-cyclohexane-1,4-diol · in 2 records
- CAQ · Catechol · in 2 records
- ES3 · 4-bromo-1H-imidazole · in 2 records
- SOA · Isatoic anhydride · in 2 records
- 2ZV · 4-methyl-3-nitropyridin-2-amine · in 1 record
- 71G · 3-aminobenzonitrile · in 1 record
- 71K · 2-methylbenzene-1,3-diamine · in 1 record
- 71M · 6-methylpyridin-2-amine · in 1 record
- SAL · 2-hydroxybenzoic acid · in 1 record
Experiment against prediction
- 4YKN chain A against the predicted model P42336: TM-score 0.83, RMSD 1.60 Å
- 4YKN chain A against the predicted model P42336: TM-score 0.83, RMSD 1.60 Å
Elsewhere
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