Research workbench
Crystal structure of CA2+-calmodulin in complex with a TRPV1 C- terminal peptide
Analyse Crystal structure of CA2+-calmodulin in complex with a TRPV1 C- terminal peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SUI
- Type
- protein
- Length
- 161 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Transient receptor potential cation channel subfamily V member 1
- UniProt
- P62158, O35433
- Ligands
- CA, SO4
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 146 | 61% helix, 4% strand | P62158 |
| B | Transient receptor potential cation channel subfamily V member 1 | protein | 15 | 53% helix, 0% strand | O35433 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.40 | 0.80 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1468 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3SUI · Crystal structure of ca2+-calmodulin in complex with a trpv1 c-terminal peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt O35433
- Elsewhere: RCSB PDB 3SUI · PDBe 3SUI · UniProt P62158 · UniProt O35433
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