Research workbench
Reduced form of ornithine hydroxylase (pvda) from pseudomonas aeruginosa
Analyse Reduced form of ornithine hydroxylase (pvda) from pseudomonas aeruginosa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S61
- Type
- protein
- Length
- 823 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-ornithine 5-monooxygenase
- EC
- 1.13.12.-
- UniProt
- Q51548
- Ligands
- FAD, ORN, NDP
- Pockets
- 7 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-ornithine 5-monooxygenase (EC 1.13.12.-) | protein | 413 | 36% helix, 26% strand | Q51548 |
| B | L-ornithine 5-monooxygenase (EC 1.13.12.-) | protein | 410 | 34% helix, 25% strand | Q51548 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- ORN · L-ornithine · ligand · 2 copies · chains A, B
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1099 | 0.83 | 0.84 | 94 | FAD, ORN, NDP |
| 2 | 937 | 0.83 | 0.84 | 89 | FAD, ORN, NDP |
| 3 | 131 | 0.53 | 0.81 | 24 | empty |
| 4 | 73 | 0.38 | 0.78 | 18 | empty |
| 5 | 95 | 0.37 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 254 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3S61 · Reduced Form of Ornithine Hydroxylase (PvdA) from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00
- Q51548 · AlphaFold monomer V2.0 prediction for L-ornithine N(5)-monooxygenase (Q51548) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q51548
- Elsewhere: RCSB PDB 3S61 · PDBe 3S61 · UniProt Q51548
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.