Research workbench
Structure and control of the actin regulatory wave complex
Analyse Structure and control of the actin regulatory wave complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3P8C
- Type
- protein
- Length
- 2,685 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytoplasmic FMR1-interacting protein 1; Nck-associated protein 1; Wiskott-aldrich…
- UniProt
- Q7L576, Q9Y2A7, Q92558, Q8WUW1, B4DSN1
- Ligands
- CL
- Pockets
- 20 · best druggability 0.90
Structure
x-ray diffraction · 5 distinct chains · 70% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytoplasmic FMR1-interacting protein 1 | protein | 1175 | 68% helix, 3% strand | Q7L576 |
| B | Nck-associated protein 1 | protein | 1086 | 71% helix, 3% strand | Q9Y2A7 |
| D | Wiskott-aldrich syndrome protein family member 1 | protein | 204 | 65% helix, 0% strand | Q92558 |
| E | Probable protein BRICK1 | protein | 64 | 91% helix, 0% strand | Q8WUW1 |
| F | Abl interactor 2 | protein | 156 | 69% helix, 3% strand | B4DSN1 |
Ligands and binding sites
- CL · Chloride ion · ion · 7 copies · chains A, B
- GOL · Glycerol · additive · 4 copies · chains A, D, E, B, F
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 998 | 0.90 | 0.91 | 105 | empty |
| 2 | 933 | 0.83 | 0.85 | 81 | empty |
| 3 | 705 | 0.82 | 0.85 | 72 | empty |
| 4 | 672 | 0.81 | 0.85 | 67 | CL |
| 5 | 534 | 0.81 | 0.87 | 61 | empty |
Interfaces
8 interfaces between chains.
- A–B · 7282 Ų buried · 48 hydrogen bonds · protein-protein
- A–D · 4011 Ų buried · 50 hydrogen bonds · protein-protein
- B–F · 2134 Ų buried · 36 hydrogen bonds · protein-protein
- D–F · 2013 Ų buried · 17 hydrogen bonds · protein-protein
- D–E · 1695 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3P8C · Structure and Control of the Actin Regulatory WAVE Complex · the same entry in another collection · chain B against B, TM-score 1.00
- Q9Y2A7 · AlphaFold monomer V2.0 prediction for nck-associated protein 1 (Q9Y2A7) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q7L576 · AlphaFold monomer V2.0 prediction for cytoplasmic FMR1-interacting protein 1 (Q7L576) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q8WUW1 · AlphaFold monomer V2.0 prediction for protein BRICK1 (Q8WUW1) · a predicted model of the same protein · chain E against A, TM-score 0.91
- Q92558 · AlphaFold monomer V2.0 prediction for wiskott-aldrich syndrome protein family member 1… · a predicted model of the same protein · chain D against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7L576
- Every structure of UniProt Q9Y2A7
- Every structure of UniProt Q92558
- Every structure of UniProt Q8WUW1
- Every structure of UniProt B4DSN1
- Elsewhere: RCSB PDB 3P8C · PDBe 3P8C · UniProt Q7L576 · UniProt Q9Y2A7 · UniProt Q92558 · UniProt Q8WUW1 · UniProt B4DSN1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.