The structure of CA2+ sensor (case-16)

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 33% strand (DSSP).

Ligands and binding sites

• CR2 · {(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
• CA · Calcium ion · metal · 2 copies · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A
• CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 cofactor (chromophore).

Compared structures

• 3O77 · The structure of Ca2+ Sensor (Case-16) · the same entry in another collection · chain A against A, TM-score 1.00
• P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain A against A, TM-score 0.37
• P11799 · AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle (P11799) · a predicted model of the same protein · chain A against A, TM-score 0.32
• P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain A against A, TM-score 0.20

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P11799
• Every structure of UniProt P42212
• Every structure of UniProt P0DP23
• Elsewhere: RCSB PDB 3O77 · PDBe 3O77 · UniProt P11799 · UniProt P42212 · UniProt P0DP23