Research workbench
Crystal structure of dht-bound androgen receptor in complex with the third motif of steroid receptor coactivator 3
Analyse Crystal structure of dht-bound androgen receptor in complex with the third… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3L3Z
- Type
- protein
- Length
- 261 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Androgen receptor; Nuclear receptor coactivator 3
- UniProt
- P10275, Q9Y6Q9
- Ligands
- DHT
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Androgen receptor | protein | 249 | 67% helix, 5% strand | P10275 |
| B | Nuclear receptor coactivator 3 | protein | 12 | 67% helix, 0% strand | Q9Y6Q9 |
Ligands and binding sites
- DHT · 5-alpha-dihydrotestosterone · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.83 | 0.98 | 20 | DHT |
| 2 | 151 | 0.62 | 0.85 | 25 | empty |
| 3 | 51 | 0.24 | 0.72 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 602 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3L3Z · Crystal structure of DHT-bound androgen receptor in complex with the third motif of… · the same entry in another collection · chain A against A, TM-score 1.00
- P10275 · AlphaFold monomer V2.0 prediction for androgen receptor (P10275) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9Y6Q9 · AlphaFold monomer V2.0 prediction for nuclear receptor coactivator 3 (Q9Y6Q9) · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10275
- Every structure of UniProt Q9Y6Q9
- Elsewhere: RCSB PDB 3L3Z · PDBe 3L3Z · UniProt P10275 · UniProt Q9Y6Q9
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