Research workbench
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex
Analyse Human growth hormone and extracellular domain of its receptor: crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HHR
- Type
- protein
- Length
- 573 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human growth hormone; Human growth hormone receptor (hghbp)
- UniProt
- P01241, P10912
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human growth hormone | protein | 184 | 67% helix, 0% strand | P01241 |
| B | Human growth hormone receptor (hghbp) | protein | 195 | 2% helix, 49% strand | P10912 |
| C | Human growth hormone receptor (hghbp) | protein | 194 | 5% helix, 47% strand | P10912 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 852 | 0.70 | 0.75 | 77 | empty |
| 2 | 212 | 0.53 | 0.77 | 32 | empty |
| 3 | 113 | 0.43 | 0.77 | 24 | empty |
| 4 | 77 | 0.41 | 0.78 | 15 | empty |
| 5 | 76 | 0.39 | 0.78 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1334 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 856 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 487 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3HHR · Human growth hormone and extracellular domain of its receptor: crystal structure of the… · the same entry in another collection · chain A against A, TM-score 1.00
- P10912 · AlphaFold monomer V2.0 prediction for growth hormone receptor (P10912) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P01241 · AlphaFold monomer V2.0 prediction for somatotropin (P01241) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01241
- Every structure of UniProt P10912
- Elsewhere: RCSB PDB 3HHR · PDBe 3HHR · UniProt P01241 · UniProt P10912
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