UniProt P01241
Somatotropin (P01241)
Somatotropin (UniProt P01241): 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01241
- Protein
- Somatotropin
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 0 records with a druggable one
Structures
18 records of P01241 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A22 | Human growth hormone bound to single receptor | x-ray diffraction | A | — | — |
| 1A22 | Human growth hormone bound to single receptor | x-ray diffraction | A | — | — |
| 1AXI | Structural plasticity at the HGH:HGHBP interface | x-ray diffraction | A | — | — |
| 1AXI | Structural plasticity at the HGH:HGHBP interface | x-ray diffraction | A | — | — |
| 1BP3 | The xray structure of a growth hormone-prolactin receptor complex | x-ray diffraction | A | — | — |
| 1BP3 | The xray structure of a growth hormone-prolactin receptor complex | x-ray diffraction | A | — | — |
| 1HGU | Human growth hormone | x-ray diffraction | A | — | — |
| 1HGU | Human growth hormone | x-ray diffraction | A | — | — |
| 1HUW | The crystal structure of affinity-matured human growth hormone at 2 ångströms resolution | x-ray diffraction | A | — | — |
| 1HUW | The crystal structure of affinity-matured human growth hormone at 2 ångströms resolution | x-ray diffraction | A | — | — |
| 1HWG | 1:2 complex of human growth hormone with its soluble binding protein | x-ray diffraction | A | — | — |
| 1HWG | 1:2 complex of human growth hormone with its soluble binding protein | x-ray diffraction | A | — | — |
| 1HWH | 1:1 complex of human growth hormone mutant G120R with its soluble binding protein | x-ray diffraction | A | — | — |
| 1HWH | 1:1 complex of human growth hormone mutant G120R with its soluble binding protein | x-ray diffraction | A | — | — |
| 3HHR | Human growth hormone and extracellular domain of its receptor: crystal structure of the complex | x-ray diffraction | A | — | — |
| 3HHR | Human growth hormone and extracellular domain of its receptor: crystal structure of the complex | x-ray diffraction | A | — | — |
| 6QIO | Ternary complex of fcrn ectodomain, fcrn binding optimised human serum albumin and the human growth… | x-ray diffraction | D | JG5 | — |
| P01241 | AlphaFold monomer V2.0 prediction for somatotropin (P01241) | predicted | A | — | 2 (best 0.31) |
Ligands
- JG5 · (2S)-6-acetamido-2-[[2-[2-[2-[[4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[4-[16-(1H-tetrazol-5-yl) hexadecanoylsulfamoyl]butanoylamino]ethoxy]ethoxy]acet yl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]a cetyl]amino]hexanoic acid · in 1 record
Experiment against prediction
- 3HHR chain A against the predicted model P01241: TM-score 0.87, RMSD 1.86 Å
- 3HHR chain A against the predicted model P01241: TM-score 0.87, RMSD 1.86 Å
- 1HWG chain A against the predicted model P01241: TM-score 0.87, RMSD 1.88 Å
- 1HWG chain A against the predicted model P01241: TM-score 0.87, RMSD 1.88 Å
- 1AXI chain A against the predicted model P01241: TM-score 0.87, RMSD 2.37 Å
- 1AXI chain A against the predicted model P01241: TM-score 0.87, RMSD 2.37 Å
- 1BP3 chain A against the predicted model P01241: TM-score 0.87, RMSD 2.07 Å
- 1BP3 chain A against the predicted model P01241: TM-score 0.87, RMSD 2.07 Å
- 1A22 chain A against the predicted model P01241: TM-score 0.86, RMSD 2.40 Å
- 1A22 chain A against the predicted model P01241: TM-score 0.86, RMSD 2.40 Å
Elsewhere
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