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Ligand · JG5

JG5 · (2S)-6-acetamido-2-[[2-[2-[2-[[4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[4-[16-(1H-tetrazol-5-yl) hexadecanoylsulfamoyl]butanoylamino]ethoxy]ethoxy]acet yl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]a cetyl]amino]hexanoic acid

JG5, (2S)-6-acetamido-2-[[2-[2-[2-[[4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[4-[16-(1H-tetrazol-5-yl) hexadecanoylsulfamoyl]butanoylamino]ethoxy]ethoxy]acet yl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]a cetyl]amino]hexanoic acid…

Component
JG5
Formula
C51 H89 N11 O19 S
Class
ligand
Structures
3
PDB entries
2

Binding sites

JG5 in 3 structures; the first of them:

  • 6QIO · Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the… · JG5 A603 · binds PHE206, ARG209, ALA210, LYS212, ALA213, VAL216, PHE228, ALA229 and 12 more
  • 6QIP · Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the… · JG5 A602 · binds PHE206, ARG209, ALA210, LYS212, ALA213, VAL216, PHE228, ALA229 and 13 more
  • 6QIO · Ternary complex of fcrn ectodomain, fcrn binding optimised human serum albumin and the… · JG5 D301 · binds PHE206, ARG209, ALA210, LYS212, ALA213, VAL216, PHE228, ALA229 and 12 more

Residues it binds most

ALA 3, LEU 3, VAL 3, LYS 3, PHE 3, SER 3, ARG 3, ASP 3, GLU 3, GLY 2 (residue and the binding sites it lines).

Found with

  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • CYS · Cysteine
  • BME · Beta-mercaptoethanol

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