UniProt P10912
Growth hormone receptor (P10912)
Growth hormone receptor (UniProt P10912): 17 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P10912
- Protein
- Growth hormone receptor
- Experimental structures
- 17
- Predicted models
- 1
Structures
18 records of P10912 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A22 | Human growth hormone bound to single receptor | x-ray diffraction | B | — | — |
| 1A22 | Human growth hormone bound to single receptor | x-ray diffraction | B | — | — |
| 1AXI | Structural plasticity at the HGH:HGHBP interface | x-ray diffraction | B | — | — |
| 1AXI | Structural plasticity at the HGH:HGHBP interface | x-ray diffraction | B | — | — |
| 1HWG | 1:2 complex of human growth hormone with its soluble binding protein | x-ray diffraction | B, C | — | — |
| 1HWG | 1:2 complex of human growth hormone with its soluble binding protein | x-ray diffraction | B, C | — | — |
| 1HWH | 1:1 complex of human growth hormone mutant G120R with its soluble binding protein | x-ray diffraction | B | — | — |
| 1HWH | 1:1 complex of human growth hormone mutant G120R with its soluble binding protein | x-ray diffraction | B | — | — |
| 1KF9 | Phage display derived variant of human growth hormone complexed with two copies of the… | x-ray diffraction | B, C, E, F | — | — |
| 1KF9 | Phage display derived variant of human growth hormone complexed with two copies of the… | x-ray diffraction | B, C, E, F | — | — |
| 2AEW | A model for growth hormone receptor activation based on subunit rotation within a receptor dimer | x-ray diffraction | A, B | — | — |
| 2AEW | A model for growth hormone receptor activation based on subunit rotation within a receptor dimer | x-ray diffraction | A, B | — | — |
| 3HHR | Human growth hormone and extracellular domain of its receptor: crystal structure of the complex | x-ray diffraction | B, C | — | — |
| 3HHR | Human growth hormone and extracellular domain of its receptor: crystal structure of the complex | x-ray diffraction | B, C | — | — |
| 5OEK | Putative active dimeric state of ghr transmembrane domain | solution nmr | A, B | — | — |
| 5OHD | Putative inactive (dormant) dimeric state of GHR transmembrane domain | solution nmr | A, B | — | — |
| 5OHD | Putative inactive (dormant) dimeric state of ghr transmembrane domain | solution nmr | A, B | — | — |
| P10912 | AlphaFold monomer V2.0 prediction for growth hormone receptor (P10912) | predicted | A | — | — |
Experiment against prediction
- 1HWG chain B against the predicted model P10912: TM-score 0.98, RMSD 0.86 Å
- 1HWG chain B against the predicted model P10912: TM-score 0.98, RMSD 0.86 Å
- 1A22 chain B against the predicted model P10912: TM-score 0.98, RMSD 0.89 Å
- 1A22 chain B against the predicted model P10912: TM-score 0.98, RMSD 0.89 Å
- 1HWH chain B against the predicted model P10912: TM-score 0.98, RMSD 0.90 Å
- 1HWH chain B against the predicted model P10912: TM-score 0.98, RMSD 0.90 Å
- 3HHR chain B against the predicted model P10912: TM-score 0.98, RMSD 1.06 Å
- 3HHR chain B against the predicted model P10912: TM-score 0.98, RMSD 1.06 Å
- 1AXI chain B against the predicted model P10912: TM-score 0.97, RMSD 1.09 Å
- 1AXI chain B against the predicted model P10912: TM-score 0.97, RMSD 1.09 Å
Elsewhere
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