Research workbench
Crystal structure of the human RAD9-HUS1-RAD1 complex
Analyse Crystal structure of the human RAD9-HUS1-RAD1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3GGR
- Type
- protein
- Length
- 806 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell cycle checkpoint control protein RAD9A; Checkpoint protein HUS1; Cell cycle…
- EC
- 3.1.11.2
- UniProt
- Q99638, O60921, O60671
- Pockets
- 16 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 15% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell cycle checkpoint control protein RAD9A (EC 3.1.11.2) | protein | 264 | 15% helix, 33% strand | Q99638 |
| B | Checkpoint protein HUS1 | protein | 278 | 15% helix, 32% strand | O60921 |
| C | Cell cycle checkpoint protein RAD1 (EC 3.1.11.2) | protein | 264 | 13% helix, 41% strand | O60671 |
Pockets
16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.77 | 0.93 | 27 | empty |
| 2 | 77 | 0.74 | 0.97 | 26 | empty |
| 3 | 52 | 0.73 | 0.99 | 24 | empty |
| 4 | 173 | 0.54 | 0.80 | 37 | empty |
| 5 | 135 | 0.51 | 0.81 | 23 | empty |
Interfaces
3 interfaces between chains.
- A–B · 834 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 799 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 781 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3GGR · Crystal Structure of the Human Rad9-Hus1-Rad1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- O60921 · AlphaFold monomer V2.0 prediction for checkpoint protein HUS1 (O60921) · a predicted model of the same protein · chain B against A, TM-score 0.93
- O60671 · AlphaFold monomer V2.0 prediction for cell cycle checkpoint protein RAD1 (O60671) · a predicted model of the same protein · chain C against A, TM-score 0.92
- Q99638 · AlphaFold monomer V2.0 prediction for cell cycle checkpoint control protein RAD9A (Q99638) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99638
- Every structure of UniProt O60921
- Every structure of UniProt O60671
- Elsewhere: RCSB PDB 3GGR · PDBe 3GGR · UniProt Q99638 · UniProt O60921 · UniProt O60671
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