Research workbench
Complex between PP2A-specific methylesterase pme-1 and PP2A core enzyme
Analyse Complex between PP2A-specific methylesterase pme-1 and PP2A core enzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3C5W
- Type
- protein
- Length
- 816 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PP2A a subunit; PP2A C subunit; PP2A-specific methylesterase pme-1
- UniProt
- P30153, P67775, Q9Y570
- Pockets
- 9 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PP2A a subunit | protein | 228 | 79% helix, 0% strand | P30153 |
| C | PP2A C subunit | protein | 294 | 36% helix, 19% strand | P67775 |
| P | PP2A-specific methylesterase pme-1 | protein | 294 | 43% helix, 20% strand | Q9Y570 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 278 | 0.66 | 0.82 | 47 | empty |
| 2 | 120 | 0.51 | 0.81 | 23 | empty |
| 3 | 260 | 0.51 | 0.74 | 31 | empty |
| 4 | 67 | 0.46 | 0.83 | 18 | empty |
| 5 | 110 | 0.42 | 0.77 | 23 | empty |
Interfaces
2 interfaces between chains.
- C–P · 1493 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 1082 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 3C5W · Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y570 · AlphaFold monomer V2.0 prediction for protein phosphatase methylesterase 1 (Q9Y570) · a predicted model of the same protein · chain P against A, TM-score 0.99
- P67775 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A catalytic… · a predicted model of the same protein · chain C against A, TM-score 0.98
- P30153 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 65 kda… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30153
- Every structure of UniProt P67775
- Every structure of UniProt Q9Y570
- Elsewhere: RCSB PDB 3C5W · PDBe 3C5W · UniProt P30153 · UniProt P67775 · UniProt Q9Y570
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