UniProt P67775
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (UniProt P67775), EC 3.1.3.16: 50 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 65 pockets. Binding sites, druggability and…
- UniProt
- P67775
- Protein
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- EC
- 3.1.3.16
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 65 · 9 records with a druggable one
Structures
51 records of P67775 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IAE | Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme. | x-ray diffraction | C, F | — | — |
| 2IAE | Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme. | x-ray diffraction | C, F | — | — |
| 2IE3 | Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins | x-ray diffraction | C | — | — |
| 2IE3 | Structure of the protein phosphatase 2A core enzyme bound to tumor- inducing toxins | x-ray diffraction | C | — | — |
| 2IE4 | Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid | x-ray diffraction | C | — | — |
| 2IE4 | Structure of the protein phosphatase 2A core enzyme bound to okadaic acid | x-ray diffraction | C | — | — |
| 2NPP | Structure of the Protein Phosphatase 2A Holoenzyme | x-ray diffraction | C, F | — | — |
| 2NPP | Structure of the protein phosphatase 2A holoenzyme | x-ray diffraction | C, F | — | — |
| 2NYL | Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl… | x-ray diffraction | C, F | — | — |
| 2NYL | Crystal structure of protein phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl… | x-ray diffraction | C, F | — | — |
| 2NYM | Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit | x-ray diffraction | C, F | — | — |
| 2NYM | Crystal structure of protein phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit | x-ray diffraction | C, F | — | — |
| 3C5W | Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme | x-ray diffraction | C | — | — |
| 3C5W | Complex between PP2A-specific methylesterase pme-1 and PP2A core enzyme | x-ray diffraction | C | — | — |
| 3DW8 | Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit | x-ray diffraction | C, F | — | — |
| 3DW8 | Structure of a protein phosphatase 2A holoenzyme with B55 subunit | x-ray diffraction | C, F | — | — |
| 3FGA | Structural Basis of PP2A and Sgo interaction | x-ray diffraction | C | — | — |
| 3FGA | Structural basis of PP2A and sgo interaction | x-ray diffraction | C | — | — |
| 3K7V | Protein phosphatase 2A core complex bound to dinophysistoxin-1 | x-ray diffraction | C | — | — |
| 3K7V | Protein phosphatase 2A core complex bound to dinophysistoxin-1 | x-ray diffraction | C | — | — |
| 3K7W | Protein phosphatase 2A core complex bound to dinophysistoxin-2 | x-ray diffraction | C | — | — |
| 3K7W | Protein phosphatase 2A core complex bound to dinophysistoxin-2 | x-ray diffraction | C | — | — |
| 3P71 | Crystal structure of the complex of LCMT-1 and PP2A | x-ray diffraction | C | — | — |
| 3P71 | Crystal structure of the complex of lcmt-1 and PP2A | x-ray diffraction | C | — | — |
| 4I5L | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation | x-ray diffraction | C, F | — | — |
| 4I5L | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for CDC6 dephosphorylation | x-ray diffraction | C, F | — | — |
| 4I5N | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation | x-ray diffraction | C, F | — | — |
| 4I5N | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for CDC6 dephosphorylation | x-ray diffraction | C, F | — | — |
| 4IYP | structure of the nPP2Ac-alpha4 complex | x-ray diffraction | C | — | — |
| 4IYP | Structure of the NPP2AC-ALPHA4 complex | x-ray diffraction | C | — | — |
| 4LAC | Crystal Structure of Protein Phosphatase 2A (PP2A) and PP2A phosphatase activator (PTPA) complex… | x-ray diffraction | C | — | — |
| 4LAC | Crystal structure of protein phosphatase 2A (PP2A) and PP2A phosphatase activator (ptpa) complex… | x-ray diffraction | C | — | — |
| 4NY3 | Human PTPA in complex with peptide | x-ray diffraction | C, D | — | — |
| 4NY3 | Human ptpa in complex with peptide | x-ray diffraction | C, D | — | — |
| 5W0W | Crystal structure of Protein Phosphatase 2A bound to TIPRL | x-ray diffraction | C, F, I, L | MN | 13 (best 0.77) |
| 5W0W | Crystal structure of protein phosphatase 2A bound to tiprl | x-ray diffraction | C, F, I, L | MN | — |
| 6NTS | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule… | electron microscopy | C | L2J, MN | 6 (best 0.76) |
| 6NTS | Protein phosphatase 2A (aalpha-B56ALPHA-calpha) holoenzyme in complex with a small molecule… | electron microscopy | C | L2J, MN | — |
| 7CUN | The structure of human Integrator-PP2A complex | electron microscopy | Q | MN | — |
| 7CUN | The structure of human integrator-PP2A complex | electron microscopy | Q | MN | — |
| 7K36 | Cryo-EM structure of stripak complex | electron microscopy | C | MN | — |
| 7SOY | The structure of the PP2A-B56GAMMA1 holoenzyme-pme-1 complex | electron microscopy | C | — | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | Q | MN | — |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | q | MN | 1 (best 0.81) |
| 8RBZ | Structure of Integrator-PP2A-SOSS-CTD post-termination complex | electron microscopy | q | MN | 2 (best 0.81) |
| 8SO0 | Cryo-EM structure of the PP2A:B55-FAM122A complex | electron microscopy | C | FE, ZN | 7 (best 0.70) |
| 8TWE | Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body | electron microscopy | C | — | 2 (best 0.65) |
| 8U1X | The structure of the PP2A-B56Delta holoenzyme mutant - E197K | electron microscopy | C | MN | 9 (best 0.83) |
| 8U89 | The structure of the PP2A-B56Delta holoenzyme mutant - E197K | electron microscopy | C | MN | 8 (best 0.69) |
| 8UWB | Crystal structure of PP2A PPP2R1A-PPP2CA-PPP2R5E phosphatase. | x-ray diffraction | C, F | MN | 13 (best 0.84) |
| P67775 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A catalytic subunit… | predicted | A | — | 4 (best 0.40) |
Ligands
Experiment against prediction
- 2IE3 chain C against the predicted model P67775: TM-score 1.00, RMSD 0.33 Å
- 2IE3 chain C against the predicted model P67775: TM-score 1.00, RMSD 0.33 Å
- 3K7V chain C against the predicted model P67775: TM-score 1.00, RMSD 0.34 Å
- 3K7V chain C against the predicted model P67775: TM-score 1.00, RMSD 0.34 Å
- 2IE4 chain C against the predicted model P67775: TM-score 1.00, RMSD 0.34 Å
- 2IE4 chain C against the predicted model P67775: TM-score 1.00, RMSD 0.34 Å
- 3K7W chain C against the predicted model P67775: TM-score 1.00, RMSD 0.35 Å
- 3K7W chain C against the predicted model P67775: TM-score 1.00, RMSD 0.35 Å
- 2NYM chain C against the predicted model P67775: TM-score 1.00, RMSD 0.38 Å
- 2NYM chain C against the predicted model P67775: TM-score 1.00, RMSD 0.38 Å
Elsewhere
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