FGA · Gamma-D-glutamic acid

Binding sites

FGA in 28 structures; the first of them:

• 4CVM · PaMurF in complex with AMP-PNP and UDP-MurNAc-tripeptide (mDAP) · FGA A1455 · binds ASN140, LEU141, ASN142, ASN143
• 1AY3 · Nodularin from nodularia spumigena · FGA A4 · binds ARG2
• 1EVA · NMR structure of cyanobacterial toxin, phosphatase-1/-2A inhibitor · FGA A6 · binds DAL1, ACB3, ARG4
• 1EVB · NMR structure of cyanobacterial toxin, phosphatase-1/-2A inhibitor · FGA A6 · binds DAL1, ACB3, ARG4
• 1EVC · NMR structure of cyanobacterial toxin, phosphatase-1/-2A inhibitor · FGA A4 · binds VAL2
• 1EVD · NMR structure of cyanobacterial toxin, phosphatase-1/-2A inhibitor · FGA A4 · binds VAL2
• 1FJM · Protein SERINE/THREONINE phosphatase-1 (alpha isoform, type 1) complexed with… · FGA M6 · binds ARG96, ARG221, HIS248, VAL250, TYR272, DAL1, LEU2, ACB3 and 1 more
• 1HHZ · Deglucobalhimycin in complex with cell wall pentapeptide · FGA D2 · binds OMY6, LYS3, DAL4
• 1LCM · NMR minimized average structure of microcystin-lr · FGA A6 · binds DAL1, LEU2, ACB3, ARG4
• 1P4N · Crystal structure of weissella viridescens FEMX:UDP-murnac- pentapeptide complex · FGA B337 · binds ILE208, THR209, HIS210, LYS338, DAL339
• 2BCD · X-ray crystal structure of protein phosphatase-1 with the marine toxin motuporin bound · FGA B4 · binds ARG96, ARG221, HIS248, VAL250, TYR272, PHE276, VAL2
• 2BDX · X-ray crystal structure of dihydromicrocystin-la bound to protein phosphatase-1 · FGA B6 · binds ARG96, ARG221, HIS248, VAL250, TYR272, DAL1, LEU2, ACB3 and 1 more
• 2IAE · Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme. · FGA M6 · binds ARG89, ARG214, HIS241, TYR267, DAL1, LEU2, ACB3, ARG4
• 2IE3 · Structure of the protein phosphatase 2A core enzyme bound to tumor- inducing toxins · FGA I6 · binds ARG89, TYR265, CYS269, DAL1, LEU2, ACB3, ARG4
• 2NPP · Structure of the protein phosphatase 2A holoenzyme · FGA X6 · binds ARG89, ARG214, TYR265, CYS269, DAL1, LEU2, ACB3, ARG4
• 2NYL · Crystal structure of protein phosphatase 2A (PP2A) holoenzyme with the catalytic subunit… · FGA G6 · binds ARG89, ARG214, HIS241, TYR265, CYS269, DAL1, LEU2, ACB3 and 1 more
• 2NYM · Crystal structure of protein phosphatase 2A (PP2A) with C-terminus truncated catalytic… · FGA G6 · binds ARG89, ARG214, HIS241, TYR265, CYS269, DAL1, LEU2, ACB3 and 1 more
• 3DW8 · Structure of a protein phosphatase 2A holoenzyme with B55 subunit · FGA G6 · binds ARG89, ARG214, HIS241, TYR265, CYS269, DAL1, LEU2, ACB3 and 1 more
• 3E7A · Crystal structure of protein phosphatase-1 bound to the natural toxin nodularin-R · FGA C4 · binds ARG96, ARG221, HIS248, VAL250, TYR272, PHE276, ARG2
• 3EGH · Crystal structure of a complex between protein phosphatase 1 alpha (PP1), the PP1 binding… · FGA E4 · binds ARG96, HIS125, ARG221, HIS248, TYR272, PHE276, ARG2
• 3FGA · Structural basis of PP2A and sgo interaction · FGA E6 · binds ARG89, ARG214, TYR265, CYS269, DAL1, LEU2, ACB3, ARG4
• 3GKR · Crystal structure of weissella viridescens FEMX:UDP-murnac-hexapeptide complex · FGA B2 · binds ILE208, THR209, LYS3, DAL4
• 4AIR · Leishmania major cysteine synthase · FGA A1327 · binds SER105, MET106

Residues it binds most

ARG 32, TYR 29, DAL 27, LEU 26, ACB 23, HIS 20, CYS 16, ASN 7, GLY 7, PHE 9 (residue and the binding sites it lines).

Found with

• 1ZN · (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
• MN · Manganese (II) ion
• DAM · N-methyl-alpha-beta-dehydroalanine
• ACB · 3-methyl-beta-D-aspartic acid
• MDH · N-methyldehydrobutyrine
• ALA · Alanine
• MG · Magnesium ion
• GOL · Glycerol
• MAA · N-methyl-L-alanine
• MUB · N-acetyl-alpha-muramic acid
• UDP · Uridine-5'-diphosphate
• ANP · Phosphoaminophosphonic acid-adenylate ester