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Ligand · OKA

OKA · Okadaic acid

OKA, Okadaic acid (C44 H68 O13, 805.0 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
OKA
Formula
C44 H68 O13
Class
ligand
Structures
8
PDB entries
4

Binding sites

OKA in 8 structures; the first of them:

  • 1JK7 · Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1 · OKA A501 · binds ARG96, HIS125, SER129, ILE130, ILE133, TYR134, TRP206, ASP220 and 7 more
  • 1U32 · Crystal structure of a Protein Phosphatase-1: Calcineurin Hybrid Bound to Okadaic Acid · OKA A501 · binds ARG96, HIS125, SER129, ILE130, ILE133, TYR134, TRP206, ASP220 and 8 more
  • 2IE4 · Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid · OKA C401 · binds ARG89, HIS118, GLN122, ILE123, TYR127, HIS191, TRP200, PRO213 and 8 more
  • 4WRI · Crystal structure of okadaic acid binding protein 2.1 · OKA A201 · binds TRP22, PHE37, VAL41, ARG44, PHE48, LEU51, MET58, ARG61 and 24 more
  • 1JK7 · Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1 · OKA A501 · binds ARG96, HIS125, SER129, ILE130, ILE133, TYR134, TRP206, ASP220 and 7 more
  • 1U32 · Crystal structure of a protein phosphatase-1: calcineurin hybrid bound to okadaic acid · OKA A501 · binds ARG96, HIS125, SER129, ILE130, ILE133, TYR134, TRP206, ASP220 and 8 more
  • 2IE4 · Structure of the protein phosphatase 2A core enzyme bound to okadaic acid · OKA C401 · binds ARG89, HIS118, GLN122, ILE123, TYR127, HIS191, TRP200, PRO213 and 8 more
  • 4WRI · Crystal structure of okadaic acid binding protein 2.1 · OKA A201 · binds TRP22, PHE37, VAL41, ARG44, PHE48, LEU51, MET58, ARG61 and 24 more

Residues it binds most

ARG 8, VAL 6, ILE 8, TYR 6, HIS 8, LEU 6, PHE 4, SER 6, TRP 8, CYS 4 (residue and the binding sites it lines).

Found with

  • MN · Manganese (II) ion
  • BME · Beta-mercaptoethanol
  • SO4 · Sulfate ion

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