UniProt P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (UniProt P30153): 33 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 68 pockets. Binding sites, druggability and…
- UniProt
- P30153
- Protein
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha…
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 68 · 7 records with a druggable one
Structures
34 records of P30153 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B3U | Crystal structure of constant regulatory domain of human PP2A, PR65ALPHA | x-ray diffraction | A | — | — |
| 1B3U | Crystal structure of constant regulatory domain of human PP2A, PR65ALPHA | x-ray diffraction | A | — | — |
| 2PKG | Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of… | x-ray diffraction | A, B | — | — |
| 2PKG | Structure of a complex between the a subunit of protein phosphatase 2A and the small T antigen of… | x-ray diffraction | A, B | — | — |
| 3C5W | Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme | x-ray diffraction | A | — | — |
| 3C5W | Complex between PP2A-specific methylesterase pme-1 and PP2A core enzyme | x-ray diffraction | A | — | — |
| 3DW8 | Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit | x-ray diffraction | A, D | — | — |
| 3DW8 | Structure of a protein phosphatase 2A holoenzyme with B55 subunit | x-ray diffraction | A, D | — | — |
| 3K7V | Protein phosphatase 2A core complex bound to dinophysistoxin-1 | x-ray diffraction | A | — | — |
| 3K7V | Protein phosphatase 2A core complex bound to dinophysistoxin-1 | x-ray diffraction | A | — | — |
| 3K7W | Protein phosphatase 2A core complex bound to dinophysistoxin-2 | x-ray diffraction | A | — | — |
| 3K7W | Protein phosphatase 2A core complex bound to dinophysistoxin-2 | x-ray diffraction | A | — | — |
| 4I5L | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation | x-ray diffraction | A, D | — | — |
| 4I5L | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for CDC6 dephosphorylation | x-ray diffraction | A, D | — | — |
| 4I5N | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation | x-ray diffraction | A, D | — | — |
| 4I5N | Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for CDC6 dephosphorylation | x-ray diffraction | A, D | — | — |
| 5W0W | Crystal structure of Protein Phosphatase 2A bound to TIPRL | x-ray diffraction | A, D, G, J | — | 14 (best 0.77) |
| 5W0W | Crystal structure of protein phosphatase 2A bound to tiprl | x-ray diffraction | A, D, G, J | — | — |
| 6IUR | A phosphatase complex STRN3-PP2Aa | x-ray diffraction | A, B, E, F | TME | — |
| 6IUR | A phosphatase complex STRN3-PP2AA | x-ray diffraction | A, B, E, F | TME | — |
| 6NTS | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule… | electron microscopy | A | L2J | 13 (best 0.76) |
| 6NTS | Protein phosphatase 2A (aalpha-B56ALPHA-calpha) holoenzyme in complex with a small molecule… | electron microscopy | A | L2J | — |
| 7CUN | The structure of human Integrator-PP2A complex | electron microscopy | P | — | — |
| 7CUN | The structure of human integrator-PP2A complex | electron microscopy | P | — | — |
| 7K36 | Cryo-EM structure of stripak complex | electron microscopy | A | — | — |
| 7SOY | The structure of the PP2A-B56GAMMA1 holoenzyme-pme-1 complex | electron microscopy | A | — | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | P | — | — |
| 8RBX | Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | electron microscopy | p | — | — |
| 8RBZ | Structure of Integrator-PP2A-SOSS-CTD post-termination complex | electron microscopy | p | — | 1 (best 0.78) |
| 8SO0 | Cryo-EM structure of the PP2A:B55-FAM122A complex | electron microscopy | A | — | 8 (best 0.81) |
| 8TWE | Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body | electron microscopy | A | — | 3 (best 0.65) |
| 8U1X | The structure of the PP2A-B56Delta holoenzyme mutant - E197K | electron microscopy | A | — | 9 (best 0.83) |
| 8UWB | Crystal structure of PP2A PPP2R1A-PPP2CA-PPP2R5E phosphatase. | x-ray diffraction | A, D | — | 20 (best 0.84) |
| P30153 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory… | predicted | A | — | — |
Ligands
Experiment against prediction
- 4I5L chain A against the predicted model P30153: TM-score 0.99, RMSD 0.85 Å
- 4I5L chain A against the predicted model P30153: TM-score 0.99, RMSD 0.85 Å
- 4I5N chain D against the predicted model P30153: TM-score 0.99, RMSD 0.88 Å
- 4I5N chain D against the predicted model P30153: TM-score 0.99, RMSD 0.88 Å
- 4I5N chain A against the predicted model P30153: TM-score 0.99, RMSD 0.90 Å
- 4I5N chain A against the predicted model P30153: TM-score 0.99, RMSD 0.90 Å
- 4I5L chain D against the predicted model P30153: TM-score 0.99, RMSD 0.92 Å
- 4I5L chain D against the predicted model P30153: TM-score 0.99, RMSD 0.92 Å
- 8TWE chain A against the predicted model P30153: TM-score 0.98, RMSD 1.01 Å
- 5W0W chain A against the predicted model P30153: TM-score 0.95, RMSD 2.13 Å
Elsewhere
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