Bovine xanthine oxidase, protease cleaved form

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 24% strand (DSSP).

Ligands and binding sites

• FES · Fe2/s2 (inorganic) cluster · ligand · 4 copies · chains A, B
• FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
• XAX · {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum · ligand · 2 copies · chains A, B
• SAL · 2-hydroxybenzoic acid · ligand · 2 copies · chains A, B
• BCT · Bicarbonate ion · ligand · 2 copies · chains A, B
• CA · Calcium ion · metal · 2 copies · chains A, B
• GOL · Glycerol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 3168 Ų buried · 57 hydrogen bonds · protein-protein

Compared structures

• 3AX7 · Bovine Xanthine Oxidase, protease cleaved form · the same entry in another collection · chain A against A, TM-score 1.00
• P80457 · AlphaFold monomer V2.0 prediction for xanthine DEHYDROGENASE/OXIDASE (P80457) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P80457
• Elsewhere: RCSB PDB 3AX7 · PDBe 3AX7 · UniProt P80457