Crystal structure of N-acetylmannosamine kinase in complex with N- acetyl mannosamine 6-phosphate and ADP.

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 24% strand (DSSP).

Ligands and binding sites

• BMX · 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-mannopyranose · ligand · chains A
• BM3 · 2-acetamido-2-deoxy-alpha-D-mannopyranose · ligand · chains A
• ADP · Adenosine-5'-diphosphate · ligand · chains A
• CA · Calcium ion · metal · 2 copies · chains A
• MG · Magnesium ion · metal · chains A
• ZN · Zinc ion · metal · chains A
• EDO · 1,2-ethanediol · additive · 4 copies · chains A
• 2PE · Nonaethylene glycol · additive · chains A
• PG4 · Tetraethylene glycol · additive · chains A
• ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 2YI1 · Crystal structure of N-Acetylmannosamine kinase in complex with N- acetyl mannosamine… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y223 · AlphaFold monomer V2.0 prediction for bifunctional udp-N- acetylglucosamine… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y223
• Elsewhere: RCSB PDB 2YI1 · PDBe 2YI1 · UniProt Q9Y223