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UPF1 helicase

Analyse UPF1 helicase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2XZP
Type: protein
Length: 621 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulator of nonsense transcripts 1
EC: 3.6.4.13
UniProt: Q92900
Pockets: 5 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulator of nonsense transcripts 1 (EC 3.6.4.13)	protein	621	39% helix, 19% strand	Q92900

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains A
MLI · Malonate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	998	0.80	0.82	73	empty
2	208	0.57	0.80	30	MLI
3	82	0.52	0.84	18	empty
4	57	0.35	0.78	16	empty
5	67	0.34	0.77	19	GOL

Compared structures

2XZP · Upf1 helicase · the same entry in another collection · chain A against A, TM-score 1.00
Q92900 · AlphaFold monomer V2.0 prediction for regulator of nonsense transcripts 1 (Q92900) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92900
Elsewhere: RCSB PDB 2XZP · PDBe 2XZP · UniProt Q92900

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