UniProt Q92900
Regulator of nonsense transcripts 1 (Q92900)
Regulator of nonsense transcripts 1 (UniProt Q92900), EC 3.6.4.12, 3.6.4.13: 20 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 23 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q92900
- Protein
- Regulator of nonsense transcripts 1
- EC
- 3.6.4.12, 3.6.4.13
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 23 · 2 records with a druggable one
Structures
21 records of Q92900 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GJK | Structural and functional insights into the human Upf1 helicase core | x-ray diffraction | A | — | — |
| 2GJK | Structural and functional insights into the human UPF1 helicase core | x-ray diffraction | A | — | — |
| 2GK6 | Structural and Functional insights into the human Upf1 helicase core | x-ray diffraction | A, B | — | — |
| 2GK6 | Structural and functional insights into the human UPF1 helicase core | x-ray diffraction | A, B | — | — |
| 2GK7 | Structural and Functional insights into the human Upf1 helicase core | x-ray diffraction | A | — | — |
| 2GK7 | Structural and functional insights into the human UPF1 helicase core | x-ray diffraction | A | — | — |
| 2IYK | Crystal structure of the UPF2-interacting domain of nonsense mediated mRNA decay factor UPF1 | x-ray diffraction | A, B | — | — |
| 2IYK | Crystal structure of the UPF2-interacting domain of nonsense mediated mRNA decay factor UPF1 | x-ray diffraction | A, B | — | — |
| 2WJV | Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 | x-ray diffraction | A, B | — | — |
| 2WJV | Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 | x-ray diffraction | A, B | — | — |
| 2WJY | Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2… | x-ray diffraction | A | — | — |
| 2WJY | Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2… | x-ray diffraction | A | — | — |
| 2XZO | Upf1 helicase - RNA complex | x-ray diffraction | A | — | — |
| 2XZO | UPF1 helicase - RNA complex | x-ray diffraction | A | — | — |
| 2XZP | Upf1 helicase | x-ray diffraction | A | — | — |
| 2XZP | UPF1 helicase | x-ray diffraction | A | — | — |
| 6EJ5 | A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an… | x-ray diffraction | A | — | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | electron microscopy | E | — | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-lsq | electron microscopy | E | — | — |
| 8RXB | Human UPF1 CH domain in complex with SMG6 peptide | x-ray diffraction | E, A, D, I, L, P | ZN | 13 (best 0.64) |
| Q92900 | AlphaFold monomer V2.0 prediction for regulator of nonsense transcripts 1 (Q92900) | predicted | A | — | 10 (best 0.84) |
Ligands
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 8RXB chain D against the predicted model Q92900: TM-score 0.98, RMSD 0.64 Å
- 8RXB chain L against the predicted model Q92900: TM-score 0.98, RMSD 0.66 Å
- 8RXB chain A against the predicted model Q92900: TM-score 0.98, RMSD 0.70 Å
- 8RXB chain I against the predicted model Q92900: TM-score 0.98, RMSD 0.71 Å
- 8RXB chain P against the predicted model Q92900: TM-score 0.98, RMSD 0.73 Å
- 8RXB chain E against the predicted model Q92900: TM-score 0.97, RMSD 0.80 Å
- 2IYK chain A against the predicted model Q92900: TM-score 0.97, RMSD 0.89 Å
- 2IYK chain A against the predicted model Q92900: TM-score 0.97, RMSD 0.89 Å
- 2GK6 chain A against the predicted model Q92900: TM-score 0.97, RMSD 1.47 Å
- 2GK6 chain A against the predicted model Q92900: TM-score 0.97, RMSD 1.47 Å
Elsewhere
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