MolNFT v1 · #53078 · protein
Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 orthorhombic form
2WJY · Regulator of nonsense transcripts 1: “Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 orthorhombic form”. X-ray diffraction, 2 ligands (ZN, SO4), 8 pockets (best druggability 0.84).…
- PDB
- 2WJY
- Type
- protein
- Length
- 773 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulator of nonsense transcripts 1
- EC
- 3.6.1.-
- UniProt
- Q92900
- Ligands
- ZN, SO4
- Pockets
- 8 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulator of nonsense transcripts 1 (EC 3.6.1.-) | protein | 773 | 35% helix, 18% strand | Q92900 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1099 | 0.84 | 0.85 | 82 | SO4 |
| 2 | 294 | 0.65 | 0.82 | 36 | empty |
| 3 | 162 | 0.55 | 0.81 | 29 | SO4 |
| 4 | 87 | 0.51 | 0.84 | 19 | empty |
| 5 | 173 | 0.46 | 0.76 | 28 | empty |
Compared structures
- 2WJY · Crystal structure of the complex between human nonsense mediated decay factors UPF1 and… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92900 · AlphaFold monomer V2.0 prediction for regulator of nonsense transcripts 1 (Q92900) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92900
- Elsewhere: RCSB PDB 2WJY · PDBe 2WJY · UniProt Q92900
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