Research workbench
Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 orthorhombic form
Analyse Crystal structure of the complex between human nonsense mediated decay factors… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WJY
- Type
- protein
- Length
- 773 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulator of nonsense transcripts 1
- EC
- 3.6.1.-
- UniProt
- Q92900
- Ligands
- ZN, SO4
- Pockets
- 8 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulator of nonsense transcripts 1 (EC 3.6.1.-) | protein | 773 | 35% helix, 18% strand | Q92900 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1099 | 0.84 | 0.85 | 82 | SO4 |
| 2 | 294 | 0.65 | 0.82 | 36 | empty |
| 3 | 162 | 0.55 | 0.81 | 29 | SO4 |
| 4 | 87 | 0.51 | 0.84 | 19 | empty |
| 5 | 173 | 0.46 | 0.76 | 28 | empty |
Compared structures
- 2WJY · Crystal structure of the complex between human nonsense mediated decay factors UPF1 and… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92900 · AlphaFold monomer V2.0 prediction for regulator of nonsense transcripts 1 (Q92900) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92900
- Elsewhere: RCSB PDB 2WJY · PDBe 2WJY · UniProt Q92900
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