Crystal structure of the complex of the carbohydrate recognition domain of human dc-sign with pseudo trimannoside mimic.

Structure

x-ray diffraction · 1 distinct chain · 23% helix, 35% strand (DSSP).

Ligands and binding sites

• 07B · dimethyl (1S,2S,4S,5S)-4,5-dihydroxycyclohexane-1,2-dicarboxylate · ligand · chains A
• AE9 · 2-azidoethanol · ligand · chains A
• MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A
• CA · Calcium ion · metal · 3 copies · chains A
• CL · Chloride ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 2XR6 · Crystal structure of the complex of the carbohydrate recognition domain of human DC-SIGN… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NNX6 · AlphaFold monomer V2.0 prediction for CD209 antigen (Q9NNX6) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NNX6
• Elsewhere: RCSB PDB 2XR6 · PDBe 2XR6 · UniProt Q9NNX6