Research workbench
Yeast cytosine deaminase D92E triple mutant bound to transition state analogue hpy
Analyse Yeast cytosine deaminase D92E triple mutant bound to transition state analogue… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2O3K
- Type
- protein
- Length
- 307 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytosine deaminase
- EC
- 3.5.4.1
- UniProt
- Q12178
- Ligands
- HPY, ZN, CA
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytosine deaminase (EC 3.5.4.1) | protein | 154 | 46% helix, 16% strand | Q12178 |
| B | Cytosine deaminase (EC 3.5.4.1) | protein | 153 | 46% helix, 19% strand | Q12178 |
Ligands and binding sites
- HPY · 4-hydroxy-3,4-dihydro-1H-pyrimidin-2-one · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- CA · Calcium ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 1562 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 2O3K · Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY · the same entry in another collection · chain A against A, TM-score 1.00
- Q12178 · AlphaFold monomer V2.0 prediction for cytosine deaminase (Q12178) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12178
- Elsewhere: RCSB PDB 2O3K · PDBe 2O3K · UniProt Q12178
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