UniProt Q12178
Cytosine deaminase (Q12178)
Cytosine deaminase (UniProt Q12178), EC 3.5.4.1: 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12178
- Protein
- Cytosine deaminase
- EC
- 3.5.4.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 10 · 3 records with a druggable one
Structures
19 records of Q12178 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OX7 | Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound | x-ray diffraction | A, B | — | — |
| 1OX7 | Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound | x-ray diffraction | A, B | — | — |
| 1P6O | The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at… | x-ray diffraction | A, B | — | — |
| 1P6O | The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at… | x-ray diffraction | A, B | — | — |
| 1RB7 | Yeast cytosine deaminase crystal form p212121 with sodium acetate. | x-ray diffraction | A, B | — | — |
| 1RB7 | Yeast cytosine deaminase crystal form P212121 with sodium acetate. | x-ray diffraction | A, B | — | — |
| 1UAQ | The crystal structure of yeast cytosine deaminase | x-ray diffraction | A, B | — | — |
| 1UAQ | The crystal structure of yeast cytosine deaminase | x-ray diffraction | A, B | — | — |
| 1YSB | Yeast Cytosine Deaminase Triple Mutant | x-ray diffraction | A, B | — | — |
| 1YSB | Yeast cytosine deaminase triple mutant | x-ray diffraction | A, B | — | — |
| 1YSD | Yeast Cytosine Deaminase Double Mutant | x-ray diffraction | A, B | — | — |
| 1YSD | Yeast cytosine deaminase double mutant | x-ray diffraction | A, B | — | — |
| 2O3K | Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY | x-ray diffraction | A, B | — | — |
| 2O3K | Yeast cytosine deaminase D92E triple mutant bound to transition state analogue hpy | x-ray diffraction | A, B | — | — |
| 8I3N | crystal structure of yeast cytosine deaminase mutant yCD-RQ | x-ray diffraction | A, B, C, D | ZN | 4 (best 0.60) |
| 8I3O | crystal structure of yeast cytosine deaminase mutant yCD-RQ-1/8SAH | x-ray diffraction | A, B, C, D | MN | 3 (best 0.59) |
| 8VLJ | Crystal structure of the cacodylate-bound yeast cytosine deaminase (closed form) | x-ray diffraction | A, B | ZN, NA | — |
| 8VLK | Crystal structure of the yeast cytosine deaminase containing both open and closed active sites | x-ray diffraction | A, B, C, D | ZN, SO4 | 3 (best 0.63) |
| Q12178 | AlphaFold monomer V2.0 prediction for cytosine deaminase (Q12178) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1YSB chain B against the predicted model Q12178: TM-score 0.98, RMSD 0.23 Å
- 1YSB chain B against the predicted model Q12178: TM-score 0.98, RMSD 0.23 Å
- 2O3K chain A against the predicted model Q12178: TM-score 1.00, RMSD 0.29 Å
- 2O3K chain A against the predicted model Q12178: TM-score 1.00, RMSD 0.29 Å
- 1UAQ chain A against the predicted model Q12178: TM-score 1.00, RMSD 0.29 Å
- 1UAQ chain A against the predicted model Q12178: TM-score 1.00, RMSD 0.29 Å
- 1UAQ chain B against the predicted model Q12178: TM-score 1.00, RMSD 0.30 Å
- 1UAQ chain B against the predicted model Q12178: TM-score 1.00, RMSD 0.30 Å
- 1YSD chain B against the predicted model Q12178: TM-score 0.98, RMSD 0.32 Å
- 1YSD chain B against the predicted model Q12178: TM-score 0.98, RMSD 0.32 Å
Elsewhere
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