Research workbench
Structure and dynamics of the acidosis-resistant A162H mutant of the switch region of troponin I bound to the regulatory domain of troponin C
Analyse Structure and dynamics of the acidosis-resistant A162H mutant of the switch… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2MZP
- Type
- protein
- Length
- 116 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles; Troponin I, cardiac muscle
- UniProt
- P63316, P19429
- Ligands
- CA
- Pockets
- 1 · best druggability 0.69
Structure
solution nmr · 2 distinct chains · 58% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Troponin C, slow skeletal and cardiac muscles | protein | 89 | 69% helix, 2% strand | P63316 |
| I | Troponin I, cardiac muscle | protein | 27 | 22% helix, 0% strand | P19429 |
Ligands and binding sites
- CA · Calcium ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.69 | 0.83 | 39 | empty |
Interfaces
1 interface between chains.
- C–I · 490 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2MZP · Structure and dynamics of the acidosis-resistant a162H mutant of the switch region of… · the same entry in another collection · chain C against C, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain C against A, TM-score 0.79
- P19429 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P19429) · a predicted model of the same protein · chain I against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Every structure of UniProt P19429
- Elsewhere: RCSB PDB 2MZP · PDBe 2MZP · UniProt P63316 · UniProt P19429
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.