UniProt P19429
Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle (P19429)
Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle (UniProt P19429): 46 experimental structures on GenesisL1, 8 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P19429
- Protein
- Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle
- Experimental structures
- 46
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 13 · 2 records with a druggable one
Structures
46 records of P19429 in the MolNFT archive: 46 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J1D | Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form | x-ray diffraction | C, F | — | — |
| 1J1D | Crystal structure of the 46KDA domain of human cardiac troponin in the CA2+ saturated form | x-ray diffraction | C, F | — | — |
| 1J1E | Crystal structure of the 52kDa domain of human cardiac troponin in the Ca2+ saturated form | x-ray diffraction | C, F | — | — |
| 1J1E | Crystal structure of the 52KDA domain of human cardiac troponin in the CA2+ saturated form | x-ray diffraction | C, F | — | — |
| 1LXF | Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac… | solution nmr | I | — | — |
| 1LXF | Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac… | solution nmr | I | — | — |
| 1MXL | Structure of cardiac troponin C-troponin I complex | solution nmr | I | — | — |
| 1MXL | Structure of cardiac troponin C-troponin I complex | solution nmr | I | — | — |
| 1OZS | C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac… | solution nmr | B | — | — |
| 1OZS | C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac… | solution nmr | B | — | — |
| 2KGB | NMR solution of the regulatory domain cardiac F77W-Troponin C in complex with the cardiac Troponin… | solution nmr | I | — | — |
| 2KGB | NMR solution of the regulatory domain cardiac F77W-troponin C in complex with the cardiac troponin… | solution nmr | I | — | — |
| 2KRD | Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch… | solution nmr | I | — | — |
| 2KRD | Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch… | solution nmr | I | — | — |
| 2L1R | The structure of the calcium-sensitizer, dfbp-o, in complex with the N-domain of troponin C and the… | solution nmr | B | — | — |
| 2L1R | The structure of the calcium-sensitizer, dfbp-O, in complex with the N-domain of troponin C and the… | solution nmr | B | — | — |
| 2MZP | Structure and dynamics of the acidosis-resistant a162H mutant of the switch region of troponin I… | solution nmr | I | — | — |
| 2MZP | Structure and dynamics of the acidosis-resistant A162H mutant of the switch region of troponin I… | solution nmr | I | — | — |
| 2N7L | NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the… | solution nmr | C | — | — |
| 2N7L | NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the… | solution nmr | C | — | — |
| 4Y99 | Core domain of human cardiac troponin | x-ray diffraction | C | — | — |
| 4Y99 | Core domain of human cardiac troponin | x-ray diffraction | C | — | — |
| 5VLN | NMR structure of the N-domain of troponin C bound to switch region of troponin I | solution nmr | A | — | — |
| 5VLN | NMR structure of the N-domain of troponin C bound to switch region of troponin I | solution nmr | A | — | — |
| 5W88 | NMR structure of the N-domain of troponin C bound to switch region of troponin I and… | solution nmr | A | 9XG | — |
| 5WCL | NMR structure of the N-domain of troponin C bound to switch region of troponin I and… | solution nmr | A | 9XG | — |
| 6KN7 | Structure of human cardiac thin filament in the calcium free state | electron microscopy | U, b | — | — |
| 6KN7 | Structure of human cardiac thin filament in the calcium free state | electron microscopy | U, b | — | — |
| 6KN8 | Structure of human cardiac thin filament in the calcium bound state | electron microscopy | U, b | — | — |
| 6MV3 | NMR structure of the cntnc-ctni chimera bound to calcium desensitizer W7 | solution nmr | A | CA, WW7 | — |
| 7JGI | NMR structure of the cntnc-ctni chimera bound to A7 | solution nmr | A | CA, V8Y | — |
| 7SC2 | Crystal structure of the N-domain of cardiac muscle troponin C tethered to the switch region of… | x-ray diffraction | A | CA | — |
| 7SC3 | Crystal structure of the N-domain of cardiac muscle troponin C tethered to the switch region of… | x-ray diffraction | A | CA | — |
| 7SUP | NMR structure of ctnc-tni chimera bound to calcium and A1 | solution nmr | A | BQ6, CA | — |
| 7SVC | NMR structure of ctnc-tni chimera bound to calcium and A2 | solution nmr | A | C9W, CA | — |
| 7SWG | Ctnc-tni chimera complexed with A1 | solution nmr | A | BQ6 | — |
| 7SWI | Ctnc-tni chimera complexed with A2 | solution nmr | A | C9W | — |
| 7SXC | Ctnc-tni chimera complexed with calcium | solution nmr | A | CA | 3 (best 0.48) |
| 7SXD | NMR solution structure TnC-TnI chimera | solution nmr | A | — | — |
| 7SXD | NMR solution structure tnc-tni chimera | solution nmr | A | — | — |
| 7UH9 | NMR structure of the cNTnC-cTnI chimera bound to W8 | solution nmr | A | CA, WW9 | 1 (best 0.66) |
| 7UH9 | NMR structure of the cntnc-ctni chimera bound to W8 | solution nmr | A | CA, WW9 | — |
| 7UHA | NMR structure of the cntnc-ctni chimera bound to W6 | solution nmr | A | CA, WW6 | — |
| 7UTI | Alternative modeling of tropomyosin in human cardiac thin filament in the calcium bound state | electron microscopy | V, a | — | — |
| 8FMO | Complex structure of K210 deletion Troponin complex with risedronate | x-ray diffraction | C, F | — | 9 (best 0.56) |
| P19429 | AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P19429) | — | — | — |
Ligands
- CA · Calcium ion · in 10 records
- 9XG · 3-methyl-N-phenylaniline · in 2 records
- BQ6 · 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide · in 2 records
- C9W · 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide · in 2 records
- WW9 · N-(7-aminoheptyl)-5-chloronaphthalene-1-sulfonamide · in 2 records
- V8Y · 7-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}heptanoic acid · in 1 record
- WW6 · N-(5-aminopentyl)-5-chloronaphthalene-1-sulfonamide · in 1 record
- WW7 · N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide · in 1 record
Experiment against prediction
- 5W88 chain A against the predicted model P63316: TM-score 0.70, RMSD 2.13 Å
- 7SC2 chain A against the predicted model P63316: TM-score 0.70, RMSD 1.21 Å
- 5WCL chain A against the predicted model P63316: TM-score 0.69, RMSD 1.93 Å
- 5VLN chain A against the predicted model P63316: TM-score 0.69, RMSD 1.71 Å
- 5VLN chain A against the predicted model P63316: TM-score 0.69, RMSD 1.71 Å
- 7SC3 chain A against the predicted model P63316: TM-score 0.67, RMSD 2.13 Å
- 6MV3 chain A against the predicted model P63316: TM-score 0.66, RMSD 2.03 Å
- 7JGI chain A against the predicted model P63316: TM-score 0.65, RMSD 2.22 Å
- 7UH9 chain A against the predicted model P63316: TM-score 0.65, RMSD 2.09 Å
- 7UH9 chain A against the predicted model P63316: TM-score 0.65, RMSD 2.09 Å
Elsewhere
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