UniProt P63316
Troponin C, slow skeletal and cardiac muscles (P63316)
Troponin C, slow skeletal and cardiac muscles (UniProt P63316): 90 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P63316
- Protein
- Troponin C, slow skeletal and cardiac muscles
- Experimental structures
- 90
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 9 · 2 records with a druggable one
Structures
91 records of P63316 in the MolNFT archive: 90 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AP4 | Regulatory domain of human cardiac troponin C in the calcium-saturated state, NMR, 40 structures | solution nmr | A | — | — |
| 1AP4 | Regulatory domain of human cardiac troponin C in the calcium-saturated state, NMR, 40 structures | solution nmr | A | — | — |
| 1IH0 | Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033 | solution nmr | A | — | — |
| 1IH0 | Structure of the C-domain of human cardiac troponin C in complex with CA2+ sensitizer emd 57033 | solution nmr | A | — | — |
| 1J1D | Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form | x-ray diffraction | A, D | — | — |
| 1J1D | Crystal structure of the 46KDA domain of human cardiac troponin in the CA2+ saturated form | x-ray diffraction | A, D | — | — |
| 1J1E | Crystal structure of the 52kDa domain of human cardiac troponin in the Ca2+ saturated form | x-ray diffraction | A, D | — | — |
| 1J1E | Crystal structure of the 52KDA domain of human cardiac troponin in the CA2+ saturated form | x-ray diffraction | A, D | — | — |
| 1LXF | Structure of the Regulatory N-domain of Human Cardiac Troponin C in Complex with Human Cardiac… | solution nmr | C | — | — |
| 1LXF | Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac… | solution nmr | C | — | — |
| 1MXL | Structure of cardiac troponin C-troponin I complex | solution nmr | C | — | — |
| 1MXL | Structure of cardiac troponin C-troponin I complex | solution nmr | C | — | — |
| 1OZS | C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac… | solution nmr | A | — | — |
| 1OZS | C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac… | solution nmr | A | — | — |
| 1SPY | Regulatory domain of human cardiac troponin C in the calcium-free state, NMR, 40 structures | solution nmr | A | — | — |
| 1SPY | Regulatory domain of human cardiac troponin C in the calcium-free state, NMR, 40 structures | solution nmr | A | — | — |
| 1WRK | Crystal structure of the N-terminal domain of human cardiac troponin C in complex with… | x-ray diffraction | A, B | — | — |
| 1WRK | Crystal structure of the N-terminal domain of human cardiac troponin C in complex with… | x-ray diffraction | A, B | — | — |
| 1WRL | Crystal structure of the N-terminal domain of human cardiac troponin C in complex with… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1WRL | Crystal structure of the N-terminal domain of human cardiac troponin C in complex with… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2JT0 | Solution structure of F104W cardiac troponin C | solution nmr | A | — | — |
| 2JT0 | Solution structure of F104W cardiac troponin C | solution nmr | A | — | — |
| 2JT3 | Solution Structure of F153W cardiac troponin C | solution nmr | A | — | — |
| 2JT3 | Solution structure of F153W cardiac troponin C | solution nmr | A | — | — |
| 2JT8 | Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac troponin C | solution nmr | A | — | — |
| 2JT8 | Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac troponin C | solution nmr | A | — | — |
| 2JTZ | Solution structure and chemical shift assignments of the F104-to-5-flurotryptophan mutant of… | solution nmr | A | — | — |
| 2JTZ | Solution structure and chemical shift assignments of the F104-to-5- flurotryptophan mutant of… | solution nmr | A | — | — |
| 2JXL | Solution structure of cardiac N-domain troponin C mutant F77W-V82A | solution nmr | A | — | — |
| 2JXL | Solution structure of cardiac N-domain troponin C mutant F77W-V82A | solution nmr | A | — | — |
| 2KDH | The Solution Structure of Human Cardiac Troponin C in complex with the Green Tea Polyphenol… | solution nmr | A | — | — |
| 2KDH | The solution structure of human cardiac troponin C in complex with the green tea polyphenol… | solution nmr | A | — | — |
| 2KFX | Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the… | solution nmr | T | — | — |
| 2KFX | Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the… | solution nmr | T | — | — |
| 2KGB | NMR solution of the regulatory domain cardiac F77W-Troponin C in complex with the cardiac Troponin… | solution nmr | C | — | — |
| 2KGB | NMR solution of the regulatory domain cardiac F77W-troponin C in complex with the cardiac troponin… | solution nmr | C | — | — |
| 2KRD | Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch… | solution nmr | C | — | — |
| 2KRD | Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch… | solution nmr | C | — | — |
| 2L1R | The structure of the calcium-sensitizer, dfbp-o, in complex with the N-domain of troponin C and the… | solution nmr | A | — | — |
| 2L1R | The structure of the calcium-sensitizer, dfbp-O, in complex with the N-domain of troponin C and the… | solution nmr | A | — | — |
| 2L98 | Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C | solution nmr | A | — | — |
| 2L98 | Structure of trans-resveratrol in complex with the cardiac regulatory protein troponin C | solution nmr | A | — | — |
| 2MKP | N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6 | solution nmr | C | — | — |
| 2MKP | N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6 | solution nmr | C | — | — |
| 2MLE | NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I | solution nmr | C | — | — |
| 2MLE | NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I | solution nmr | C | — | — |
| 2MLF | NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring… | solution nmr | C | — | — |
| 2MLF | NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring… | solution nmr | C | — | — |
| 2MZP | Structure and dynamics of the acidosis-resistant a162H mutant of the switch region of troponin I… | solution nmr | C | — | — |
| 2MZP | Structure and dynamics of the acidosis-resistant A162H mutant of the switch region of troponin I… | solution nmr | C | — | — |
| 2N79 | The structural and functional effects of the Familial Hypertrophic Cardiomyopathy-linked cardiac… | solution nmr | C | — | — |
| 2N79 | The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac… | solution nmr | C | — | — |
| 2N7L | NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the… | solution nmr | C | — | — |
| 2N7L | NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the… | solution nmr | C | — | — |
| 3RV5 | Crystal structure of human cardiac troponin C regulatory domain in complex with cadmium and… | x-ray diffraction | A, B, C, D | — | — |
| 3RV5 | Crystal structure of human cardiac troponin C regulatory domain in complex with cadmium and… | x-ray diffraction | A, B, C, D | — | — |
| 3SD6 | Crystal structure of the amino-terminal domain of human cardiac troponin C in complex with cadmium… | x-ray diffraction | A | — | — |
| 3SD6 | Crystal structure of the amino-terminal domain of human cardiac troponin C in complex with cadmium… | x-ray diffraction | A | — | — |
| 3SWB | Crystal structure of the amino-terminal domain of human cardiac troponin C in complex with cadmium… | x-ray diffraction | A | — | — |
| 3SWB | Crystal structure of the amino-terminal domain of human cardiac troponin C in complex with cadmium… | x-ray diffraction | A | — | — |
31 records more on the page itself.
Ligands
- CA · Calcium ion · in 11 records
- 9XG · 3-methyl-N-phenylaniline · in 2 records
- BQ6 · 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide · in 2 records
- C9W · 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide · in 2 records
- WW9 · N-(7-aminoheptyl)-5-chloronaphthalene-1-sulfonamide · in 2 records
- V8Y · 7-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}heptanoic acid · in 1 record
- WW6 · N-(5-aminopentyl)-5-chloronaphthalene-1-sulfonamide · in 1 record
- WW7 · N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide · in 1 record
Experiment against prediction
- 1WRL chain B against the predicted model P63316: TM-score 0.97, RMSD 0.60 Å
- 1WRL chain B against the predicted model P63316: TM-score 0.97, RMSD 0.60 Å
- 1WRL chain A against the predicted model P63316: TM-score 0.96, RMSD 0.68 Å
- 1WRL chain A against the predicted model P63316: TM-score 0.96, RMSD 0.68 Å
- 1WRK chain B against the predicted model P63316: TM-score 0.96, RMSD 0.72 Å
- 1WRK chain B against the predicted model P63316: TM-score 0.96, RMSD 0.72 Å
- 1WRK chain A against the predicted model P63316: TM-score 0.95, RMSD 0.77 Å
- 1WRK chain A against the predicted model P63316: TM-score 0.95, RMSD 0.77 Å
- 1WRL chain D against the predicted model P63316: TM-score 0.95, RMSD 0.80 Å
- 1WRL chain D against the predicted model P63316: TM-score 0.95, RMSD 0.80 Å
Elsewhere
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