Ligand · TFP
TFP · 10-[3-(4-methyl-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine
TFP, 10-[3-(4-methyl-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine (C21 H24 F3 N3 S, 407.5 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (7 PDB entries). Every binding site with its residues within 4.5 Å…
- Component
- TFP
- Formula
- C21 H24 F3 N3 S
- Class
- ligand
- Structures
- 14
- PDB entries
- 7
Binding sites
TFP in 14 structures; the first of them:
- 1A29 · Calmodulin complexed with trifluoperazine (1:2 complex) · TFP A153 · binds GLU11, PHE92, ILE100, LEU105, MET124, ILE125, GLU127, ALA128 and 3 more
- 1CTR · Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex · TFP A153 · binds GLU11, PHE92, ILE100, LEU105, GLU123, MET124, GLU127, ALA128 and 3 more
- 1LIN · Calmodulin complexed with trifluoperazine (1:4 complex) · TFP A153 · binds GLU11, PHE92, ILE100, LEU105, MET124, ILE125, GLU127, ALA128 and 3 more
- 1WRK · Crystal structure of the N-terminal domain of human cardiac troponin C in complex with… · TFP A202 · binds LEU41, VAL44, MET45, LEU48, GLN50, GLU56, MET60, PHE77 and 7 more
- 1WRL · Crystal structure of the N-terminal domain of human cardiac troponin C in complex with… · TFP A202 · binds MET45, LEU48, GLN50, PRO52, GLU56, MET60, MET80, MET81 and 6 more
- 3KO0 · Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor · TFP A201 · binds SER44, PHE45, LEU46, GLY47, CYS81, ILE82, MET85, CYS86 and 6 more
Residues it binds most
PHE 126, LEU 132, MET 92, SER 110, GLU 74, CYS 80, ILE 92, GLY 44, ASP 40, ALA 46 (residue and the binding sites it lines).
Found with
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