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Human annexin A2 with heparin tetrasaccharide bound

Analyse Human annexin A2 with heparin tetrasaccharide bound in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HYU
Type: protein
Length: 308 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A2
UniProt: P07355
Ligands: UAP, SGN, IDS, CA
Pockets: 5 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A2	protein	308	73% helix, 0% strand	P07355

Ligands and binding sites

UAP · 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid · ligand · chains A
SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · sugar · 2 copies · chains A
IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · sugar · chains A
CA · Calcium ion · metal · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.48	0.82	23	empty
2	77	0.46	0.82	21	empty
3	97	0.37	0.75	17	empty
4	66	0.32	0.76	15	empty
5	50	0.27	0.74	14	empty

Compared structures

2HYU · Human Annexin A2 with heparin tetrasaccharide bound · the same entry in another collection · chain A against A, TM-score 1.00
P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07355
Elsewhere: RCSB PDB 2HYU · PDBe 2HYU · UniProt P07355

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