UniProt P07355

Annexin A2 (P07355)

Annexin A2 (UniProt P07355): 65 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 95 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P07355
Protein: Annexin A2
Experimental structures: 65
Predicted models: 1
Ligands: 2
Pockets: 95 · 14 records with a druggable one

Structures

66 records of P07355 in the MolNFT archive: 65 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1W7B	Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein.	x-ray diffraction	A	—	—
1W7B	Annexin A2: does it induce membrane aggregation by a new multimeric state of the protein.	x-ray diffraction	A	—	—
1XJL	Structure of human annexin A2 in the presence of calcium ions	x-ray diffraction	A, B	—	—
1XJL	Structure of human annexin A2 in the presence of calcium ions	x-ray diffraction	A, B	—	—
2HYU	Human Annexin A2 with heparin tetrasaccharide bound	x-ray diffraction	A	—	—
2HYU	Human annexin A2 with heparin tetrasaccharide bound	x-ray diffraction	A	—	—
2HYV	Human Annexin A2 with heparin hexasaccharide bound	x-ray diffraction	A	—	—
2HYV	Human annexin A2 with heparin hexasaccharide bound	x-ray diffraction	A	—	—
2HYW	Human Annexin A2 with Calcium bound	x-ray diffraction	A, B	—	—
2HYW	Human annexin A2 with calcium bound	x-ray diffraction	A, B	—	—
4DRW	Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an…	x-ray diffraction	A, B, C, D	—	—
4DRW	Crystal structure of the ternary complex between S100A10, an annexin A2 N-terminal peptide and an…	x-ray diffraction	A, B, C, D	—	—
4FTG	The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer	x-ray diffraction	C, D	—	—
4FTG	The crystal structure of an ahnak peptide in complex with the S100A10/ANXA2 heterotetramer	x-ray diffraction	C, D	—	—
4HRH	Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide	x-ray diffraction	A, B	—	—
4HRH	Crystal structure of P11-annexin A2(N-terminal) fusion protein in complex with SMARCA3 peptide	x-ray diffraction	A, B	—	—
5LPU	Crystal structure of Annexin A2 complexed with S100A4	x-ray diffraction	A, B	CA	9 (best 0.76)
5LPU	Crystal structure of annexin A2 complexed with S100A4	x-ray diffraction	A, B	ACE, CA	—
5LPX	Crystal structure of PKC phosphorylation-mimicking mutant (S26E) Annexin A2	x-ray diffraction	A	CA	—
5LPX	Crystal structure of PKC phosphorylation-mimicking mutant (S26E) annexin A2	x-ray diffraction	A	CA	—
5LQ0	Crystal structure of TYR24 phosphorylated annexin A2 at 2.9 a resolution	x-ray diffraction	A, B	CA	—
5LQ2	Crystal structure of Tyr24 phosphorylated Annexin A2 at 3.4 A resolution	x-ray diffraction	A, B	CA	—
5LQ2	Crystal structure of TYR24 phosphorylated annexin A2 at 3.4 a resolution	x-ray diffraction	A, B	CA	—
5N7D	MAGI-1 complexed with a RSK1 peptide	x-ray diffraction	A, B	CA	—
5N7D	Magi-1 complexed with a RSK1 peptide	x-ray diffraction	A, B	CA	—
5N7F	MAGI-1 complexed with a pRSK1 peptide	x-ray diffraction	A, B	CA	—
5N7F	Magi-1 complexed with a PRSK1 peptide	x-ray diffraction	A, B	CA	—
5N7G	MAGI-1 complexed with a synthetic pRSK1 peptide	x-ray diffraction	A, B	CA	12 (best 0.75)
5N7G	Magi-1 complexed with a synthetic PRSK1 peptide	x-ray diffraction	A, B	CA	—
6T58	Structure determination of the transactivation domain of p53 in complex with S100A4 using annexin…	x-ray diffraction	A, B	CA	14 (best 0.75)
6T58	Structure determination of the transactivation domain of P53 in complex with S100A4 using annexin…	x-ray diffraction	A, B	CA	—
6TWQ	MAGI1_2 complexed with a 16E6 peptide	x-ray diffraction	B, A	CA	—
6TWU	MAGI1_2 complexed with a phosphomimetic 16E6 peptide	x-ray diffraction	A, B	CA	—
6TWX	MAGI1_2 complexed with a phosphorylated 16E6 peptide	x-ray diffraction	A, B	CA	—
6TWY	MAGI1_2 complexed with a phosphomimetic RSK1 peptide	x-ray diffraction	A, B	CA	10 (best 0.76)
6TWY	MAGI1_2 complexed with a phosphomimetic RSK1 peptide	x-ray diffraction	A, B	CA	—
7DTO	Human annexin A2 with C132-C261 intramolecular disulfide bond	x-ray diffraction	A	—	—
7EQ7	Co-crystal structure analysis of annexin A2 and 5ALPHA-eal	x-ray diffraction	A	CA	—
7NMI	Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone	x-ray diffraction	B	CA	—
7NMI	Transactivation domain of P53 in complex with S100P, using annexin A2 as crystallization chaperone	x-ray diffraction	B	CA	—
7P70	The PDZ-domain of SNTB1 complexed with the PDZ-binding motif of HPV35-E6	x-ray diffraction	A	CA	3 (best 0.68)
7P70	The PDZ-domain of SNTB1 complexed with the PDZ-binding motif of HPV35- E6	x-ray diffraction	A	CA	—
7P71	The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6	x-ray diffraction	A, B	CA	—
7P72	The PDZ domain of SNX27 complexed with the PDZ-binding motif of MERS-E	x-ray diffraction	A	CA	4 (best 0.60)
7P72	The PDZ domain of SNX27 complexed with the PDZ-binding motif of MERS-E	x-ray diffraction	A	CA	—
7P73	The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1	x-ray diffraction	A	CA	4 (best 0.63)
7P73	The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1	x-ray diffraction	A	CA	—
7P74	The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1	x-ray diffraction	A	CA	2 (best 0.74)
7P74	The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ- binding motif of RSK1	x-ray diffraction	A	CA	—
7PC3	The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1	x-ray diffraction	A	CA	—
7PC4	The PDZ domain of SNTB1 complexed with the PDZ-binding motif of HTLV1-TAX1	x-ray diffraction	A	CA	4 (best 0.62)
7PC4	The PDZ domain of SNTB1 complexed with the PDZ-binding motif of HTLV1- TAX1	x-ray diffraction	A	CA	—
7PC5	The third PDZ domain of PDZD7 complexed with the PDZ-binding motif of EXOC4	x-ray diffraction	A	CA	4 (best 0.62)
7PC5	The third PDZ domain of PDZD7 complexed with the PDZ-binding motif of EXOC4	x-ray diffraction	A	CA	—
7PC7	The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN	x-ray diffraction	A, B	CA	10 (best 0.65)
7PC7	The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of pten	x-ray diffraction	A, B	CA	—
7PC8	The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ- binding motif of RSK1	x-ray diffraction	A, B	CA	—
7PC9	The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1	x-ray diffraction	B, A	CA	—
7PCB	The PDZ domain of SNX27 fused with ANXA2	x-ray diffraction	A	CA	—
7QQL	The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1	x-ray diffraction	C, A, B	CA	—

6 records more on the page itself.

Ligands

CA · Calcium ion · in 48 records
ACE · Acetyl group · in 1 record

Experiment against prediction

2HYW chain A against the predicted model P07355: TM-score 1.00, RMSD 0.34 Å
2HYW chain A against the predicted model P07355: TM-score 1.00, RMSD 0.34 Å
2HYW chain B against the predicted model P07355: TM-score 1.00, RMSD 0.37 Å
2HYW chain B against the predicted model P07355: TM-score 1.00, RMSD 0.37 Å
1XJL chain B against the predicted model P07355: TM-score 1.00, RMSD 0.43 Å
1XJL chain B against the predicted model P07355: TM-score 1.00, RMSD 0.43 Å
7EQ7 chain A against the predicted model P07355: TM-score 1.00, RMSD 0.41 Å
7ZVX chain B against the predicted model P07355: TM-score 1.00, RMSD 0.44 Å
7ZVX chain A against the predicted model P07355: TM-score 1.00, RMSD 0.45 Å
5LQ2 chain A against the predicted model P07355: TM-score 0.99, RMSD 0.50 Å

Elsewhere

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