Research workbench
NMR solution structure of the human spliceosomal protein complex P14- SF3B155
Analyse NMR solution structure of the human spliceosomal protein complex P14- SF3B155 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FHO
- Type
- protein
- Length
- 134 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spliceosomal protein SF3B155; Spliceosomal protein P14
- UniProt
- O75533, Q9Y3B4
- Pockets
- 2 · best druggability 0.38
Structure
solution nmr · 2 distinct chains · 16% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spliceosomal protein SF3B155 | protein | 47 | 11% helix, 6% strand | O75533 |
| B | Spliceosomal protein P14 | protein | 87 | 20% helix, 30% strand | Q9Y3B4 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.38 | 0.78 | 17 | empty |
| 2 | 91 | 0.37 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 948 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2FHO · NMR solution structure of the human spliceosomal protein complex p14-SF3b155 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y3B4 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 6 (Q9Y3B4) · a predicted model of the same protein · chain B against A, TM-score 0.85
- O75533 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 1 (O75533) · a predicted model of the same protein · chain A against A, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75533
- Every structure of UniProt Q9Y3B4
- Elsewhere: RCSB PDB 2FHO · PDBe 2FHO · UniProt O75533 · UniProt Q9Y3B4
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