Research workbench
Structure of the rb C-terminal domain bound to an E2F1-DP1 heterodimer
Analyse Structure of the rb C-terminal domain bound to an E2F1-DP1 heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AZE
- Type
- protein
- Length
- 294 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor dp-1; Transcription factor E2F1; Retinoblastoma-associated protein
- UniProt
- Q14186, Q01094, P06400
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription factor dp-1 | protein | 149 | 54% helix, 17% strand | Q14186 |
| B | Transcription factor E2F1 | protein | 101 | 46% helix, 25% strand | Q01094 |
| C | Retinoblastoma-associated protein | protein | 44 | 30% helix, 11% strand | P06400 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 243 | 0.58 | 0.78 | 33 | empty |
| 2 | 83 | 0.35 | 0.75 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3174 Ų buried · 42 hydrogen bonds · protein-protein
- A–C · 785 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 735 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 2AZE · Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- Q14186 · AlphaFold monomer V2.0 prediction for transcription factor dp-1 (Q14186) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q01094 · AlphaFold monomer V2.0 prediction for transcription factor E2F1 (Q01094) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P06400 · AlphaFold monomer V2.0 prediction for retinoblastoma-associated protein (P06400) · a predicted model of the same protein · chain C against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14186
- Every structure of UniProt Q01094
- Every structure of UniProt P06400
- Elsewhere: RCSB PDB 2AZE · PDBe 2AZE · UniProt Q14186 · UniProt Q01094 · UniProt P06400
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