MolNFT v1 · #335414 · protein
AlphaFold monomer V2.0 prediction for retinoblastoma-associated protein (P06400)
P06400: “AlphaFold monomer V2.0 prediction for retinoblastoma-associated protein (P06400)”. 15 pockets (best druggability 0.80). MolNFT v1 #335414 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P06400
- Type
- protein
- Length
- 928 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x40B9C9d5F084D34d026E9d5Dd10501AcdF6d6152
- Molecule
- Retinoblastoma-associated protein
- UniProt
- P06400
- Pockets
- 15 · best druggability 0.80
Structure
1 distinct chain · 56% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinoblastoma-associated protein | protein | 928 | 56% helix, 2% strand | P06400 |
Pockets
15 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 981 | 0.80 | 0.82 | 90 | empty |
| 2 | 224 | 0.64 | 0.83 | 31 | empty |
| 3 | 100 | 0.56 | 0.85 | 18 | empty |
| 4 | 223 | 0.46 | 0.73 | 21 | empty |
| 5 | 72 | 0.41 | 0.80 | 18 | empty |
Compared structures
- 4ELJ · Crystal structure of the inactive retinoblastoma protein phosphorylated at T373 · an experimental structure of the same protein · chain A against A, TM-score 0.63
- 4ELJ · Crystal structure of the inactive retinoblastoma protein phosphorylated at T373 · an experimental structure of the same protein · chain A against A, TM-score 0.63
- 4ELL · Structure of the inactive retinoblastoma protein pocket domain · an experimental structure of the same protein · chain A against B, TM-score 0.37
- 4ELL · Structure of the inactive retinoblastoma protein pocket domain · an experimental structure of the same protein · chain A against B, TM-score 0.37
- 3POM · Crystal structure of the unliganded retinoblastoma protein pocket domain · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 3POM · Crystal Structure of the Unliganded Retinoblastoma Protein Pocket Domain · an experimental structure of the same protein · chain A against A, TM-score 0.36
- 2R7G · Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1… · an experimental structure of the same protein · chain A against C, TM-score 0.36
- 2R7G · Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1… · an experimental structure of the same protein · chain A against C, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06400
- Elsewhere: UniProt P06400 · AlphaFold DB P06400
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