MolNFT v1 · #90511 · protein

Crystal structure of the inactive retinoblastoma protein phosphorylated at T373

4ELJ · Retinoblastoma-associated protein: “Crystal structure of the inactive retinoblastoma protein phosphorylated at T373”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1 #90511 on GenesisL1: 3D structure, binding sites…

PDB: 4ELJ
Type: protein
Length: 590 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retinoblastoma-associated protein
UniProt: P06400
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retinoblastoma-associated protein	protein	590	71% helix, 2% strand	P06400

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	941	0.73	0.77	88	empty
2	124	0.58	0.84	18	empty
3	108	0.45	0.78	17	empty
4	104	0.44	0.78	15	empty
5	94	0.36	0.75	18	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4ELJ · Crystal structure of the inactive retinoblastoma protein phosphorylated at T373 · the same entry in another collection · chain A against A, TM-score 1.00
P06400 · AlphaFold monomer V2.0 prediction for retinoblastoma-associated protein (P06400) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06400
Elsewhere: RCSB PDB 4ELJ · PDBe 4ELJ · UniProt P06400

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