Research workbench
Structure of the archaeal initiation factor EIF2 alpha-gamma heterodimer from sulfolobus solfataricus complexed with gdpnp
Analyse Structure of the archaeal initiation factor EIF2 alpha-gamma heterodimer from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AHO
- Type
- protein
- Length
- 660 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor 2 gamma subunit; Translation initiation factor 2 alpha…
- UniProt
- Q980A5, Q97Z79
- Ligands
- GNP, MG, ZN
- Pockets
- 10 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor 2 gamma subunit | protein | 401 | 16% helix, 38% strand | Q980A5 |
| B | Translation initiation factor 2 alpha subunit | protein | 259 | 40% helix, 23% strand | Q97Z79 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 298 | 0.58 | 0.77 | 36 | empty |
| 2 | 179 | 0.55 | 0.80 | 21 | empty |
| 3 | 163 | 0.49 | 0.77 | 25 | empty |
| 4 | 149 | 0.42 | 0.75 | 30 | empty |
| 5 | 76 | 0.42 | 0.80 | 21 | MG, GNP |
Interfaces
1 interface between chains.
- A–B · 913 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2AHO · Structure of the archaeal initiation factor eIF2 alpha-gamma heterodimer from Sulfolobus… · the same entry in another collection · chain B against B, TM-score 1.00
- Q980A5 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q97Z79 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit alpha… · a predicted model of the same protein · chain B against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q980A5
- Every structure of UniProt Q97Z79
- Elsewhere: RCSB PDB 2AHO · PDBe 2AHO · UniProt Q980A5 · UniProt Q97Z79
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.