Research workbench
The yeast actin val 159 asn mutant complex with human gelsolin segment 1.
Analyse The yeast actin val 159 asn mutant complex with human gelsolin segment 1. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YVN
- Type
- protein
- Length
- 497 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (actin); Protein (gelsolin)
- UniProt
- P60010, P06396
- Ligands
- ATP, MG, CA, SO4
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (actin) | protein | 372 | 44% helix, 20% strand | P60010 |
| G | Protein (gelsolin) | protein | 125 | 23% helix, 34% strand | P06396 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- CA · Calcium ion · metal · chains G
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.72 | 0.85 | 37 | empty |
| 2 | 400 | 0.71 | 0.83 | 54 | MG, ATP |
| 3 | 161 | 0.45 | 0.75 | 21 | empty |
| 4 | 75 | 0.30 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–G · 1046 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1YVN · The yeast actin val 159 asn mutant complex with human gelsolin segment 1. · the same entry in another collection · chain A against A, TM-score 1.00
- P60010 · AlphaFold monomer V2.0 prediction for actin (P60010) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P06396 · AlphaFold monomer V2.0 prediction for gelsolin (P06396) · a predicted model of the same protein · chain G against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60010
- Every structure of UniProt P06396
- Elsewhere: RCSB PDB 1YVN · PDBe 1YVN · UniProt P60010 · UniProt P06396
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.