UniProt P60010
Actin (P60010)
Actin (UniProt P60010), EC 3.6.4.-: 19 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P60010
- Protein
- Actin
- EC
- 3.6.4.-
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 68 · 8 records with a druggable one
Structures
20 records of P60010 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YAG | Structure of the yeast actin-human gelsolin segment 1 complex | x-ray diffraction | A | — | — |
| 1YAG | Structure of the yeast actin-human gelsolin segment 1 complex | x-ray diffraction | A | — | — |
| 1YVN | The yeast actin val 159 asn mutant complex with human gelsolin segment 1. | x-ray diffraction | A | — | — |
| 1YVN | The yeast actin val 159 asn mutant complex with human gelsolin segment 1. | x-ray diffraction | A | — | — |
| 5NBL | Crystal structure of the Arp4-N-actin(APO-state) heterodimer bound by a nanobody | x-ray diffraction | C, D | — | 17 (best 0.88) |
| 5NBL | Crystal structure of the ARP4-N-ACTIN(APO-state) heterodimer bound by a nanobody | x-ray diffraction | C, D | — | — |
| 5NBM | Crystal structure of the Arp4-N-actin(ATP-state) heterodimer bound by a nanobody | x-ray diffraction | C, D | CA, ATP | 18 (best 0.88) |
| 5NBM | Crystal structure of the ARP4-N-ACTIN(ATP-state) heterodimer bound by a nanobody | x-ray diffraction | C, D | CA, ATP | — |
| 5NBN | Crystal structure of the Arp4-N-actin-Arp8-Ino80HSA module of INO80 | x-ray diffraction | C, D | CA, ATP, LAR | — |
| 5NBN | Crystal structure of the ARP4-N-actin-ARP8-INO80HSA module of INO80 | x-ray diffraction | C, D | CA, ATP, LAR | — |
| 5Y81 | NuA4 TEEAA sub-complex | electron microscopy | G | — | 4 (best 0.87) |
| 5Y81 | NUA4 teeaa sub-complex | electron microscopy | G | — | — |
| 7VVY | Tra module of NUA4 | electron microscopy | G | MG, ATP | — |
| 7VVZ | NUA4 bound to the nucleosome | electron microscopy | G | MG, ATP | — |
| 7YFN | Core module of the NuA4 complex in S. cerevisiae | electron microscopy | A | — | 5 (best 0.89) |
| 7YFP | The NuA4 histone acetyltransferase complex from S. cerevisiae | electron microscopy | A | — | 2 (best 0.90) |
| 8A5A | Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of INO80 | electron microscopy | V | ATP, MG | 11 (best 0.89) |
| 8A5O | Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of S. cerevisiae INO80 | electron microscopy | V | AGS, MG | 8 (best 0.88) |
| 8ESC | Structure of the Yeast NuA4 Histone Acetyltransferase Complex | electron microscopy | A | — | 3 (best 0.90) |
| P60010 | AlphaFold monomer V2.0 prediction for actin (P60010) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5NBN chain C against the predicted model P60010: TM-score 0.99, RMSD 0.66 Å
- 5NBN chain C against the predicted model P60010: TM-score 0.99, RMSD 0.66 Å
- 8A5O chain V against the predicted model P60010: TM-score 0.99, RMSD 0.74 Å
- 8A5A chain V against the predicted model P60010: TM-score 0.99, RMSD 0.81 Å
- 5NBN chain D against the predicted model P60010: TM-score 0.99, RMSD 0.86 Å
- 5NBN chain D against the predicted model P60010: TM-score 0.99, RMSD 0.86 Å
- 5NBM chain D against the predicted model P60010: TM-score 0.99, RMSD 0.93 Å
- 5NBM chain D against the predicted model P60010: TM-score 0.99, RMSD 0.93 Å
- 5NBM chain C against the predicted model P60010: TM-score 0.99, RMSD 0.93 Å
- 5NBM chain C against the predicted model P60010: TM-score 0.99, RMSD 0.93 Å
Elsewhere
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