UniProt P06396

Gelsolin (P06396)

Gelsolin (UniProt P06396): 106 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P06396
Protein: Gelsolin
Experimental structures: 106
Predicted models: 1
Ligands: 4
Pockets: 8 · 1 record with a druggable one

Structures

107 records of P06396 in the MolNFT archive: 106 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1C0F	Crystal structure of dictyostelium caatp-actin in complex with gelsolin segment 1	x-ray diffraction	S	—	—
1C0F	Crystal structure of dictyostelium caatp-actin in complex with gelsolin segment 1	x-ray diffraction	S	—	—
1C0G	Crystal structure of 1:1 complex between gelsolin segment 1 and a DICTYOSTELIUM/TETRAHYMENA chimera…	x-ray diffraction	S	—	—
1C0G	Crystal structure of 1:1 complex between gelsolin segment 1 and a DICTYOSTELIUM/TETRAHYMENA chimera…	x-ray diffraction	S	—	—
1D4X	Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at…	x-ray diffraction	G	—	—
1D4X	Crystal structure of caenorhabditis elegans mg-ATP actin complexed with human gelsolin segment 1 at…	x-ray diffraction	G	—	—
1DEJ	Crystal structure of a DICTYOSTELIUM/TETRAHYMENA chimera actin (mutant 646…	x-ray diffraction	S	—	—
1DEJ	Crystal structure of a DICTYOSTELIUM/TETRAHYMENA chimera actin (mutant 646…	x-ray diffraction	S	—	—
1EQY	Complex between rabbit muscle alpha-actin: human gelsolin domain 1	x-ray diffraction	S	—	—
1EQY	Complex between rabbit muscle alpha-actin: human gelsolin domain 1	x-ray diffraction	S	—	—
1ESV	Complex between latrunculin A:RABBIT muscle alpha ACTIN:HUMAN gelsolin domain 1	x-ray diffraction	S	—	—
1ESV	Complex between latrunculin A:RABBIT muscle alpha ACTIN:HUMAN gelsolin domain 1	x-ray diffraction	S	—	—
1H1V	gelsolin G4-G6/actin complex	x-ray diffraction	G	—	—
1H1V	Gelsolin G4-G6/ACTIN complex	x-ray diffraction	G	—	—
1KCQ	Human Gelsolin Domain 2 with a Cd2+ bound	x-ray diffraction	A	—	—
1KCQ	Human gelsolin domain 2 with a CD2+ bound	x-ray diffraction	A	—	—
1MDU	Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1)	x-ray diffraction	A, D	—	—
1MDU	Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (gs-1)	x-ray diffraction	A, D	—	—
1NLV	Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin…	x-ray diffraction	G	—	—
1NLV	Crystal structure of dictyostelium discoideum actin complexed with ca ATP and human gelsolin…	x-ray diffraction	G	—	—
1NM1	Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A…	x-ray diffraction	G	—	—
1NM1	Crystal structure of D. dicsoideum actin complexed with gelsolin segment 1 and mg ATP at 1.8 a…	x-ray diffraction	G	—	—
1NMD	Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of…	x-ray diffraction	G	—	—
1NMD	Crystal structure of D. discoideum actin-gelsolin segment 1 complex crystallized in presence of…	x-ray diffraction	G	—	—
1P8X	The Calcium-Activated C-terminal half of gelsolin	x-ray diffraction	A, B, C	—	—
1P8X	The calcium-activated C-terminal half of gelsolin	x-ray diffraction	A, B, C	—	—
1P8Z	Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156	x-ray diffraction	G	—	—
1P8Z	Complex between rabbit muscle alpha-actin: human gelsolin residues VAL26-GLU156	x-ray diffraction	G	—	—
1SOL	A PIP2 and F-actin-binding site of gelsolin, residue 150-169 (NMR, averaged structure)	solution nmr	A	—	—
1SOL	A PIP2 and F-actin-binding site of gelsolin, residue 150-169 (NMR, averaged structure)	solution nmr	A	—	—
1T44	Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation	x-ray diffraction	G	—	—
1T44	Structural basis of actin sequestration by thymosin-B4: implications for ARP2/3 activation	x-ray diffraction	G	—	—
1YAG	Structure of the yeast actin-human gelsolin segment 1 complex	x-ray diffraction	G	—	—
1YAG	Structure of the yeast actin-human gelsolin segment 1 complex	x-ray diffraction	G	—	—
1YVN	The yeast actin val 159 asn mutant complex with human gelsolin segment 1.	x-ray diffraction	G	—	—
1YVN	The yeast actin val 159 asn mutant complex with human gelsolin segment 1.	x-ray diffraction	G	—	—
2FF3	Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin	x-ray diffraction	A	—	—
2FF3	Crystal structure of gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin	x-ray diffraction	A	—	—
2FF6	Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin	x-ray diffraction	G	—	—
2FF6	Crystal structure of gelsolin domain 1:CIBOULOT domain 2 hybrid in complex with actin	x-ray diffraction	G	—	—
2FH1	C-terminal half of gelsolin soaked in low calcium at pH 4.5	x-ray diffraction	A, B, C	—	—
2FH1	C-terminal half of gelsolin soaked in low calcium at pH 4.5	x-ray diffraction	A, B, C	—	—
2FH2	C-terminal half of gelsolin soaked in EGTA at pH 4.5	x-ray diffraction	A, B, C	—	—
2FH2	C-terminal half of gelsolin soaked in egta at pH 4.5	x-ray diffraction	A, B, C	—	—
2FH3	C-terminal half of gelsolin soaked in low calcium at pH 8	x-ray diffraction	A, B, C	—	—
2FH3	C-terminal half of gelsolin soaked in low calcium at pH 8	x-ray diffraction	A, B, C	—	—
2FH4	C-terminal half of gelsolin soaked in EGTA at pH 8	x-ray diffraction	A, B, C	—	—
2FH4	C-terminal half of gelsolin soaked in egta at pH 8	x-ray diffraction	A, B, C	—	—
3A5L	Crystal Structure of a Dictyostelium P109A Mg2+-Actin in Complex with Human Gelsolin Segment 1	x-ray diffraction	S	—	—
3A5L	Crystal structure of a dictyostelium P109A MG2+-actin in complex with human gelsolin segment 1	x-ray diffraction	S	—	—
3A5M	Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1	x-ray diffraction	S	—	—
3A5M	Crystal structure of a dictyostelium P109I MG2+-actin in complex with human gelsolin segment 1	x-ray diffraction	S	—	—
3A5N	Crystal Structure of a Dictyostelium P109A Ca2+-Actin in Complex with Human Gelsolin Segment 1	x-ray diffraction	S	—	—
3A5N	Crystal structure of a dictyostelium P109A CA2+-actin in complex with human gelsolin segment 1	x-ray diffraction	S	—	—
3A5O	Crystal Structure of a Dictyostelium P109I Ca2+-Actin in Complex with Human Gelsolin Segment 1	x-ray diffraction	S	—	—
3A5O	Crystal structure of a dictyostelium P109I CA2+-actin in complex with human gelsolin segment 1	x-ray diffraction	S	—	—
3CI5	Complex of Phosphorylated Dictyostelium Discoideum Actin with Gelsolin	x-ray diffraction	G	—	—
3CI5	Complex of phosphorylated dictyostelium discoideum actin with gelsolin	x-ray diffraction	G	—	—
3CIP	Complex of Dictyostelium Discoideum Actin with Gelsolin	x-ray diffraction	G	—	—
3CIP	Complex of dictyostelium discoideum actin with gelsolin	x-ray diffraction	G	—	—

47 records more on the page itself.

Ligands

CA · Calcium ion · in 8 records
SO4 · Sulfate ion · in 5 records
NA · Sodium ion · in 4 records
CL · Chloride ion · in 2 records

Experiment against prediction

6JEG chain B against the predicted model P06396: TM-score 1.00, RMSD 0.46 Å
6JEH chain B against the predicted model P06396: TM-score 1.00, RMSD 0.53 Å
6JEH chain B against the predicted model P06396: TM-score 1.00, RMSD 0.53 Å
7P2B chain B against the predicted model P06396: TM-score 1.00, RMSD 0.56 Å
6JEG chain A against the predicted model P06396: TM-score 1.00, RMSD 0.57 Å
6JEH chain A against the predicted model P06396: TM-score 1.00, RMSD 0.58 Å
6JEH chain A against the predicted model P06396: TM-score 1.00, RMSD 0.58 Å
6Q9R chain B against the predicted model P06396: TM-score 1.00, RMSD 0.67 Å
6QBF chain A against the predicted model P06396: TM-score 0.99, RMSD 0.68 Å
6QBF chain A against the predicted model P06396: TM-score 0.99, RMSD 0.68 Å

Elsewhere

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