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Structure of small GTPase human rheb in complex with gppnhp

Analyse Structure of small GTPase human rheb in complex with gppnhp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XTR
Type: protein
Length: 170 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTP-binding protein rheb
UniProt: Q15382
Ligands: GNP, MG
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTP-binding protein rheb	protein	170	36% helix, 28% strand	Q15382

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.50	0.78	29	MG, GNP
2	50	0.26	0.73	13	empty

Compared structures

1XTR · Structure of small GTPase human Rheb in complex with GppNHp · the same entry in another collection · chain A against A, TM-score 1.00
Q15382 · AlphaFold monomer V2.0 prediction for GTP-binding protein rheb (Q15382) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15382
Elsewhere: RCSB PDB 1XTR · PDBe 1XTR · UniProt Q15382

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