UniProt Q15382
GTP-binding protein Rheb (Q15382)
GTP-binding protein Rheb (UniProt Q15382): 23 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15382
- Protein
- GTP-binding protein Rheb
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 52 · 7 records with a druggable one
Structures
24 records of Q15382 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XTQ | Structure of small GTPase human Rheb in complex with GDP | x-ray diffraction | A | — | — |
| 1XTQ | Structure of small GTPase human rheb in complex with GDP | x-ray diffraction | A | — | — |
| 1XTR | Structure of small GTPase human Rheb in complex with GppNHp | x-ray diffraction | A | — | — |
| 1XTR | Structure of small GTPase human rheb in complex with gppnhp | x-ray diffraction | A | — | — |
| 1XTS | Structure of small GTPase human Rheb in complex with GTP | x-ray diffraction | A | — | — |
| 1XTS | Structure of small GTPase human rheb in complex with GTP | x-ray diffraction | A | — | — |
| 3SEA | Structure of Rheb-Y35A mutant in GDP- and GMPPNP-bound forms | x-ray diffraction | A, B | — | — |
| 3SEA | Structure of rheb-Y35A mutant in GDP- and gmppnp-bound forms | x-ray diffraction | A, B | — | — |
| 3T5G | Structure of fully modified farnesylated Rheb in complex with PDE6D | x-ray diffraction | A | — | — |
| 3T5G | Structure of fully modified farnesylated rheb in complex with PDE6D | x-ray diffraction | A | — | — |
| 5YXH | Structure of Rheb-GDP | x-ray diffraction | A, B, C, D | GDP, MG | 10 (best 0.75) |
| 5YXH | Structure of rheb-GDP | x-ray diffraction | A, B, C, D | GDP, MG | — |
| 6BCU | Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom | electron microscopy | S, R | GTP, MG | 4 (best 0.78) |
| 6BSX | Crystal structure of rheb in complex with compound 1 at 1.65A resolution | x-ray diffraction | A, B, C, D | MG, GDP, E7S | 12 (best 0.75) |
| 6BSX | Crystal structure of rheb in complex with compound 1 at 1.65A resolution | x-ray diffraction | A, B, C, D | MG, GDP, E7S | — |
| 6BT0 | Crystal structure of rheb in complex with compound NR1 | x-ray diffraction | A, B, C, D | MG, GDP, E7V | 9 (best 0.79) |
| 6BT0 | Crystal structure of rheb in complex with compound NR1 | x-ray diffraction | A, B, C, D | MG, GDP, E7V | — |
| 7BTA | Crystal structure of Rheb D60K mutant bound to GDP | x-ray diffraction | A, B | GDP, PO4 | 3 (best 0.76) |
| 7BTA | Crystal structure of rheb D60K mutant bound to GDP | x-ray diffraction | A, B | GDP, PO4 | — |
| 7BTC | Crystal structure of Rheb Y35N mutant bound to GDP | x-ray diffraction | A, B, C, D | GDP | 10 (best 0.65) |
| 7BTC | Crystal structure of rheb Y35N mutant bound to GDP | x-ray diffraction | A, B, C, D | GDP | — |
| 7BTD | Crystal structure of Rheb Y35N mutant bound to GppNHp | x-ray diffraction | A | MG, GNP | 2 (best 0.43) |
| 7BTD | Crystal structure of rheb Y35N mutant bound to gppnhp | x-ray diffraction | A | MG, GNP | — |
| Q15382 | AlphaFold monomer V2.0 prediction for GTP-binding protein rheb (Q15382) | predicted | A | — | 2 (best 0.52) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 10 records
- MG · Magnesium ion · in 9 records
- E7S · (5,6-dimethyl-1H-benzimidazol-2-yl)methanol · in 2 records
- E7V · 4-bromo-6-[(3,4-dichlorophenyl)sulfanyl]-1-{[4-(dimethylcarbamoyl)phenyl]methyl}-1H-indole-2-carboxylic acid · in 2 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 2 records
- PO4 · Phosphate ion · in 2 records
- GTP · Guanosine-5'-triphosphate · in 1 record
Experiment against prediction
- 1XTR chain A against the predicted model Q15382: TM-score 0.99, RMSD 0.61 Å
- 1XTR chain A against the predicted model Q15382: TM-score 0.99, RMSD 0.61 Å
- 7BTD chain A against the predicted model Q15382: TM-score 0.99, RMSD 0.62 Å
- 7BTD chain A against the predicted model Q15382: TM-score 0.99, RMSD 0.62 Å
- 1XTS chain A against the predicted model Q15382: TM-score 0.99, RMSD 0.63 Å
- 1XTS chain A against the predicted model Q15382: TM-score 0.99, RMSD 0.63 Å
- 7BTA chain B against the predicted model Q15382: TM-score 0.98, RMSD 0.61 Å
- 7BTA chain B against the predicted model Q15382: TM-score 0.98, RMSD 0.61 Å
- 7BTC chain A against the predicted model Q15382: TM-score 0.98, RMSD 0.68 Å
- 7BTC chain A against the predicted model Q15382: TM-score 0.98, RMSD 0.68 Å
Elsewhere
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