Research workbench
Crystal structure of trichosanthin-NADPH complex at 1.7 ångströms resolution reveals active-site architecture
Analyse Crystal structure of trichosanthin-NADPH complex at 1.7 ångströms resolution… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TCS
- Type
- protein
- Length
- 247 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trichosanthin
- EC
- 3.2.2.22
- UniProt
- P09989
- Ligands
- NDP
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trichosanthin (EC 3.2.2.22) | protein | 247 | 40% helix, 25% strand | P09989 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.50 | 0.80 | 18 | NDP |
| 2 | 72 | 0.33 | 0.74 | 13 | empty |
Compared structures
- 1TCS · Crystal structure of trichosanthin-NADPH complex at 1.7 ångströms resolution reveals… · the same entry in another collection · chain A against A, TM-score 1.00
- P09989 · AlphaFold monomer V2.0 prediction for ribosome-inactivating protein alpha-trichosanthin… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09989
- Elsewhere: RCSB PDB 1TCS · PDBe 1TCS · UniProt P09989
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.