Research workbench
Structure of nucleotide-free scallop myosin S1
Analyse Structure of nucleotide-free scallop myosin S1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SR6
- Type
- protein
- Length
- 1,100 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin heavy chain, striated muscle; Myosin regulatory light chain, striated adductor…
- UniProt
- P24733, P13543, P07291
- Ligands
- MG, CA, SO4
- Pockets
- 13 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin heavy chain, striated muscle | protein | 801 | 48% helix, 13% strand | P24733 |
| B | Myosin regulatory light chain, striated adductor muscle | protein | 144 | 30% helix, 4% strand | P13543 |
| C | Myosin essential light chain, striated adductor muscle | protein | 155 | 52% helix, 6% strand | P07291 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains B
- CA · Calcium ion · metal · chains C
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1011 | 0.80 | 0.81 | 114 | SO4 |
| 2 | 120 | 0.68 | 0.89 | 26 | empty |
| 3 | 560 | 0.67 | 0.77 | 59 | empty |
| 4 | 74 | 0.62 | 0.90 | 24 | empty |
| 5 | 255 | 0.62 | 0.80 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–C · 2157 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1886 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 234 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1SR6 · Structure of nucleotide-free scallop myosin S1 · the same entry in another collection · chain A against A, TM-score 1.00
- P07291 · AlphaFold monomer V2.0 prediction for myosin essential light chain, striated adductor… · a predicted model of the same protein · chain C against A, TM-score 0.97
- P13543 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain, striated adductor… · a predicted model of the same protein · chain B against A, TM-score 0.84
- P24733 · AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24733
- Every structure of UniProt P13543
- Every structure of UniProt P07291
- Elsewhere: RCSB PDB 1SR6 · PDBe 1SR6 · UniProt P24733 · UniProt P13543 · UniProt P07291
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