MolNFT v1 · #255837 · protein
AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733)
P24733: “AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733)”. 8 pockets (best druggability 0.76). MolNFT v1 #255837 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P24733
- Type
- protein
- Length
- 1,938 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb3c0C983Fc44934AC589D7131C08a72544EBB92E
- Molecule
- Myosin heavy chain, striated muscle
- UniProt
- P24733
- Pockets
- 8 · best druggability 0.76
Structure
1 distinct chain · 74% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin heavy chain, striated muscle | protein | 1938 | 74% helix, 6% strand | P24733 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 761 | 0.76 | 0.81 | 63 | empty |
| 2 | 857 | 0.74 | 0.78 | 72 | empty |
| 3 | 933 | 0.72 | 0.77 | 90 | empty |
| 4 | 557 | 0.70 | 0.79 | 56 | empty |
| 5 | 67 | 0.68 | 0.94 | 26 | empty |
Compared structures
- 1QVI · Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 ångström… · an experimental structure of the same protein · chain A against A, TM-score 0.39
- 1QVI · Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom… · an experimental structure of the same protein · chain A against A, TM-score 0.39
- 1DFL · Scallop myosin S1 complexed with MGADP:VANADATE-transition state · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 1DFL · Scallop myosin S1 complexed with MGADP:VANADATE-transition state · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 2W4T · Isometrically contracting insect asynchronous flight muscle · an experimental structure of the same protein · chain A against C, TM-score 0.36
- 2W4T · Isometrically contracting insect asynchronous flight muscle · an experimental structure of the same protein · chain A against C, TM-score 0.36
- 2W4W · Isometrically contracting insect asynchronous flight muscle quick frozen after a quick… · an experimental structure of the same protein · chain A against C, TM-score 0.36
- 2W4W · Isometrically contracting insect asynchronous flight muscle quick frozen after a quick… · an experimental structure of the same protein · chain A against C, TM-score 0.36
- 1KK7 · Scallop myosin in the near rigor conformation · an experimental structure of the same protein · chain A against A, TM-score 0.35
- 1KK7 · Scallop myosin in the near rigor conformation · an experimental structure of the same protein · chain A against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24733
- Elsewhere: UniProt P24733 · AlphaFold DB P24733
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