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AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733)

Analyse AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
P24733
Type
protein
Length
1,938 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0xb3c0C983Fc44934AC589D7131C08a72544EBB92E
Molecule
Myosin heavy chain, striated muscle
UniProt
P24733
Pockets
8 · best druggability 0.76

Structure

1 distinct chain · 74% helix, 6% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AMyosin heavy chain, striated muscleprotein193874% helix, 6% strandP24733

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
17610.760.8163empty
28570.740.7872empty
39330.720.7790empty
45570.700.7956empty
5670.680.9426empty

Compared structures

  • 1QVI · Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 ångström… · an experimental structure of the same protein · chain A against A, TM-score 0.39
  • 1QVI · Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom… · an experimental structure of the same protein · chain A against A, TM-score 0.39
  • 1DFL · Scallop myosin S1 complexed with MGADP:VANADATE-transition state · an experimental structure of the same protein · chain A against A, TM-score 0.38
  • 1DFL · Scallop myosin S1 complexed with MGADP:VANADATE-transition state · an experimental structure of the same protein · chain A against A, TM-score 0.38
  • 2W4T · Isometrically contracting insect asynchronous flight muscle · an experimental structure of the same protein · chain A against C, TM-score 0.36
  • 2W4T · Isometrically contracting insect asynchronous flight muscle · an experimental structure of the same protein · chain A against C, TM-score 0.36
  • 2W4W · Isometrically contracting insect asynchronous flight muscle quick frozen after a quick… · an experimental structure of the same protein · chain A against C, TM-score 0.36
  • 2W4W · Isometrically contracting insect asynchronous flight muscle quick frozen after a quick… · an experimental structure of the same protein · chain A against C, TM-score 0.36
  • 1KK7 · Scallop myosin in the near rigor conformation · an experimental structure of the same protein · chain A against A, TM-score 0.35
  • 1KK7 · Scallop myosin in the near rigor conformation · an experimental structure of the same protein · chain A against A, TM-score 0.35

Analyse

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