Research workbench
Structure of the regulatory domain of scallop myosin at 2.8 ångströms resolution
Analyse Structure of the regulatory domain of scallop myosin at 2.8 ångströms resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SCM
- Type
- protein
- Length
- 347 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin heavy chain; Myosin regulatory light chain; Myosin essential light chain
- UniProt
- P24733, P13543, P07291
- Ligands
- CA
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 56% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin heavy chain | protein | 60 | 88% helix, 0% strand | P24733 |
| B | Myosin regulatory light chain | protein | 138 | 53% helix, 6% strand | P13543 |
| C | Myosin essential light chain | protein | 149 | 47% helix, 7% strand | P07291 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.43 | 0.78 | 23 | empty |
| 2 | 95 | 0.37 | 0.76 | 22 | empty |
| 3 | 74 | 0.33 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1844 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 1806 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 217 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1SCM · Structure of the regulatory domain of scallop myosin at 2.8 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P07291 · AlphaFold monomer V2.0 prediction for myosin essential light chain, striated adductor… · a predicted model of the same protein · chain C against A, TM-score 0.95
- P13543 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain, striated adductor… · a predicted model of the same protein · chain B against A, TM-score 0.90
- P24733 · AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733) · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24733
- Every structure of UniProt P13543
- Every structure of UniProt P07291
- Elsewhere: RCSB PDB 1SCM · PDBe 1SCM · UniProt P24733 · UniProt P13543 · UniProt P07291
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