Research workbench

Mouse TRPM8 in lmng in the presence of calcium

Analyse Mouse TRPM8 in lmng in the presence of calcium in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7WRB
Type: protein
Length: 3,720 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily M member 8
UniProt: Q8R4D5
Ligands: CA
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 63% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily M member 8	protein	930	63% helix, 5% strand	Q8R4D5

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	498	0.85	0.91	36	empty
2	893	0.77	0.80	84	CA
3	829	0.77	0.80	80	CA
4	877	0.77	0.80	77	empty
5	827	0.77	0.80	74	CA

Interfaces

6 interfaces between chains.

A–D · 4034 Å² buried · 33 hydrogen bonds · protein-protein
B–C · 4025 Å² buried · 33 hydrogen bonds · protein-protein
C–D · 4025 Å² buried · 33 hydrogen bonds · protein-protein
A–B · 4019 Å² buried · 33 hydrogen bonds · protein-protein
A–C · 55 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7WRB · Mouse TRPM8 in LMNG in the presence of calcium · the same entry in another collection · chain C against C, TM-score 1.00
Q8R4D5 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8R4D5
Elsewhere: RCSB PDB 7WRB · PDBe 7WRB · UniProt Q8R4D5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.