UniProt Q8R4D5
Transient receptor potential cation channel subfamily M member 8 (Q8R4D5)
Transient receptor potential cation channel subfamily M member 8 (UniProt Q8R4D5): 24 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 373 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8R4D5
- Protein
- Transient receptor potential cation channel subfamily M member 8
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 373 · 19 records with a druggable one
Structures
25 records of Q8R4D5 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7WRA | Mouse TRPM8 in LMNG in ligand-free state | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 7WRA | Mouse TRPM8 in lmng in ligand-free state | electron microscopy | A, B, C, D | — | — |
| 7WRB | Mouse TRPM8 in LMNG in the presence of calcium | electron microscopy | A, B, C, D | CA | 20 (best 0.85) |
| 7WRB | Mouse TRPM8 in lmng in the presence of calcium | electron microscopy | A, B, C, D | CA | — |
| 7WRC | Mouse TRPM8 in LMNG in the presence of calcium, icilin and PI(4,5)P2 | electron microscopy | A, B, C, D | CA, KX7 | 20 (best 0.84) |
| 7WRC | Mouse TRPM8 in lmng in the presence of calcium, icilin and PI(4,5)P2 | electron microscopy | A, B, C, D | CA, KX7 | — |
| 7WRD | Mouse TRPM8 in LMNG in the presence of calcium and icilin | electron microscopy | A, B, C, D | CA, KX7 | 20 (best 0.84) |
| 7WRD | Mouse TRPM8 in lmng in the presence of calcium and icilin | electron microscopy | A, B, C, D | CA, KX7 | — |
| 7WRE | Mouse TRPM8 in lipid nanodiscs in the presence of calcium and icilin | electron microscopy | A, B, C, D | CA, KX7 | 20 (best 0.83) |
| 7WRE | Mouse TRPM8 in lipid nanodiscs in the presence of calcium and icilin | electron microscopy | A, B, C, D | CA, KX7 | — |
| 7WRF | Mouse TRPM8 in lipid nanodiscs in the presence of calcium, icilin and PI(4,5)P2 | electron microscopy | A, B, C, D | CA, NA, KX7 | 20 (best 0.84) |
| 7WRF | Mouse TRPM8 in lipid nanodiscs in the presence of calcium, icilin and PI(4,5)P2 | electron microscopy | A, B, C, D | CA, KX7 | — |
| 8E4L | The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | electron microscopy | A, B, C, D | CA, UL9, ULO, PIO | 20 (best 0.84) |
| 8E4M | The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | electron microscopy | A, B, C, D | PIO, ULO, CA | 20 (best 0.81) |
| 8E4N | The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | electron microscopy | A, B, C, D | PIO | 20 (best 0.81) |
| 8E4O | The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | electron microscopy | A, D, B, C | PIO | 20 (best 0.82) |
| 8E4P | Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | electron microscopy | A, B, C, D | Y01 | 20 (best 0.80) |
| 9B6D | Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state | electron microscopy | A, B, C, D | Y01 | 20 (best 0.81) |
| 9B6E | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 | electron microscopy | A, B, C, D | T14, Y01 | 20 (best 0.83) |
| 9B6F | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850 | electron microscopy | A, B, C, D | Y01, A1AIY | 20 (best 0.83) |
| 9B6G | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMTB | electron microscopy | A, B, C, D | Y01, LQ7, NAG | 20 (best 0.83) |
| 9B6H | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the… | electron microscopy | A, B, C, D | T14, Y01, ULO, NAG | 20 (best 0.85) |
| 9B6J | Cryo-EM structure of the mouse TRPM8 channel in complex with PI(4,5)P2 and Ca2+ | electron microscopy | A, B, C, D | CA, PIO | 20 (best 0.80) |
| 9B6K | Cryo-EM structure of the mouse TRPM8 channel in complex with Ca2+ in the absence of PI(4,5)P2 | electron microscopy | A, B, C, D | CA | 20 (best 0.82) |
| Q8R4D5 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M… | predicted | A | — | 13 (best 0.76) |
Ligands
- CA · Calcium ion · in 14 records
- KX7 · Icilin · in 8 records
- Y01 · Cholesterol hemisuccinate · in 6 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 5 records
- ULO · nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- T14 · 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene · in 2 records
- A1AIY · (8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide · in 1 record
- LQ7 · N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide · in 1 record
- NA · Sodium ion · in 1 record
- UL9 · 3-isothiocyanatoprop-1-ene · in 1 record
Experiment against prediction
- 7WRC chain A against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.22 Å
- 7WRC chain A against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.22 Å
- 7WRC chain B against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.22 Å
- 7WRC chain C against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.22 Å
- 7WRC chain D against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.22 Å
- 7WRF chain A against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.27 Å
- 7WRF chain A against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.27 Å
- 7WRF chain C against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.27 Å
- 7WRF chain B against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.27 Å
- 7WRF chain D against the predicted model Q8R4D5: TM-score 0.89, RMSD 3.27 Å
Elsewhere
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